Lessons learned from mouse models of hemolytic transfusion reactions.
Lessons learned from mouse models of hemolytic transfusion reactions.
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DOI：
10.1097/moh.0b013e328311f40a
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发表时间：
2008-11
影响因子：
3.2
通讯作者：
Spitalnik SL
中科院分区：
文献类型：
--
作者：
Hod EA;Zimring JC;Spitalnik SL
Hemolytic transfusion reactions (HTRs) are potentially fatal complications of blood transfusions. Many studies, primarily performed in vitro, have provided a great deal of insight into the initiating events of HTRs; however, it is not clear how they are modulated and how they combine to lead to one or more of the final common pathways. Recently developed mouse HTR models now make it possible to enhance our understanding of the pathogenesis of HTRs; this will allow for the rational design of specific therapies to prevent or ameliorate this serious complication in transfusion medicine. Mouse models support the hypothesis that “cytokine storm” plays an important role in the pathogenesis of HTRs. Nitric oxide and endothelial cell dysfunction are also implicated in the pathophysiology of these reactions. In addition, the intriguing phenomenon of “antigen loss,” where antigen crosslinking by alloantibody leads to antigen removal rather than RBC clearance, has been modeled and explored. Finally, these mouse models were used to evaluate new therapeutic targets employing complement receptor 1 peptide homologues and the anti-macrophage agent, liposomal clodronate. Models of HTRs are valuable for gaining a better understanding of the pathophysiology of these potentially fatal complications of blood transfusion. The participation of various inflammatory mediators was shown to play a role in these reactions in vivo. This knowledge will lead to novel treatment options.
DOI：
10.1084/jem.151.6.1424
发表时间：
1980-06-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Ferreira A;David CS;Nussenzweig V
通讯作者：
Nussenzweig V