Effects of 1,25 dihydroxyvitamin D3 administration on circadian mineral rhythms in humans.
Effects of 1,25 dihydroxyvitamin D3 administration on circadian mineral rhythms in humans.
复制标题
1,25 二羟基维生素 D3 给药对人类昼夜节律的影响。
DOI：
10.1007/bf02553700
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发表时间：
1985
影响因子：
4.2
通讯作者：
Mizruchi,M
中科院分区：
文献类型：
--
作者：
Markowitz,ME;Rosen,JF;Mizruchi,M
1,25 Dihydroxyvitamin D3(1,25(OH)2D3) (2.0 μg) was given intramuscularly to 6 healthy adult males. Twenty-four circadian patterns of blood-ionized calcium (Ca2+), serum phosphate (Pi), and total calcium (CaT) were assessed pre- and posthormone administration. Correlations of mean mineral rhythms with normative models were significant for each mineral pattern on both study days. Mean Ca2+and CaTrhythms became weakly correlated after hormone treatment (r=.39). A small but statistically significant increment in the 24 h grand mean Ca2+concentration was observed on the treatment day compared with the baseline day. However, this increment is less than the year-to-year variability in the grand mean mineral concentrations derived from the same subjects studied under baseline conditions previously. These data indicate that acute parenteral administration of near-physiological (2.0 μg) doses of 1,25(OH)2D3appears to have no major effect on circadian mineral pattern shape or mean mineral concentrations.
