Effect of Treatment on Imaging, Clinical, and Serologic Assessments of Disease Activity in Large-vessel Vasculitis
Effect of Treatment on Imaging, Clinical, and Serologic Assessments of Disease Activity in Large-vessel Vasculitis
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DOI：
10.3899/jrheum.181222
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发表时间：
2020-01-01
影响因子：
3.9
通讯作者：
Grayson, Peter C.
中科院分区：
文献类型：
--
作者：
Banerjee, Shubhasree;Quinn, Kaitlin A.;Grayson, Peter C.
Objective.大血管炎（LVV）的疾病活动性传统上通过临床和血清学变量而不是血管成像来评估。本研究确定了治疗对18 F-氟脱氧葡萄糖正电子发射断层扫描（FDG-PET）血管活性的影响，并与基于临床和血清学的评估相关。巨细胞动脉炎（GCA）或大动脉炎（TA）的患者进行了前瞻性评估，在6个月的时间间隔在一个观察队列。在随访访视前至少3个月进行治疗变化，并将其分类为增加、减少或不变。在每次访视时测定影像学（FDG-PET定性分析）、临床和血清学（红细胞沉降率、C反应蛋白）评估，并在间隔访视期间进行比较。在156次访视期间，对52例LVV患者（GCA = 31; TA = 21）进行了系列评估。分别在36、23和32次访视间隔记录治疗增加、减少或不变。当治疗增加时，通过影像学、临床和炎症标志物，疾病活动度显著降低（p
Objective. Disease activity in large-vessel vasculitis (LVV) is traditionally assessed by clinical and serological variables rather than vascular imaging. This study determined the effect of treatment on 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) vascular activity in relation to clinical- and serologic-based assessments.Methods. Patients with giant cell arteritis (GCA) or Takayasu arteritis (TA) were prospectively evaluated at 6-month intervals in an observational cohort. Treatment changes were made at least 3 months before the followup visit and categorized as increased, decreased, or unchanged. Imaging (FDG-PET qualitative analysis), clinical, and serologic (erythrocyte sedimentation rate, C-reactive protein) assessments were determined at each visit and compared over interval visits.Results. Serial assessments were performed in 52 patients with LVV (GCA = 31; TA = 21) over 156 visits. Increased, decreased, or unchanged therapy was recorded for 36-, 23-, and 32-visit intervals, respectively. When treatment was increased, there was significant reduction in disease activity by imaging, clinical, and inflammatory markers (p