Health-related behavior and the use of hormone replacement therapy.
Health-related behavior and the use of hormone replacement therapy.
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健康相关行为和激素替代疗法的使用。
DOI：
10.1002/pds.820
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发表时间：
2004
期刊：
影响因子：
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通讯作者：
Benedetti,Andrea
中科院分区：
文献类型：
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作者：
Csizmadi,Ilona;Collet,Jean-Paul;Boivin,Jean-Francois;Hanley,JamesA;Benedetti,Andrea
PurposeTo study health‐related differences between hormone replacement therapy（HRT）users and nonusers among colorectal cases and women without diagnosed cancer.MethodsData from the Saskatchewan Health population‐based databases were used to determine the use of HRT，oral contraceptives（OCs），cardiovascular system（CVS）drugs，central nervous system（CNS）drugs，在3338名诊断为结直肠癌的妇女和13025名未诊断为癌症的妇女中使用NSAID和维生素。医生的访问和乙状结肠镜检查程序也被确定。结果在未诊断为癌症的妇女中，HRT与CVS药物相关（OR=1.23，95%CI：1.10-1.37），中枢神经系统药物（OR=1.96，95%CI：1.72-2.23），其他激素（OR=1.12，95%CI：1.01-1.24），处方维生素（OR= 1.37，95%CI：1.22-1.55），NSAID（OR=1.41，95%CI：1.18-1.68），在索引日期前3-5年接受过乙状结肠镜检查（OR=1.33，95%CI：1.12-1.59）和指定索引日期前第5年内15次或以上的医生访视（OR=2.0，95%CI：1.77-2.35）。在诊断为结直肠癌的女性中观察到类似的结果，但HRT的使用与乙状结肠镜检查无关。这些因素中的一些可能有助于研究HRT的健康益处的选择偏差。版权所有© 2003年约翰威利父子有限公司。
PurposeTo study health‐related differences between hormone replacement therapy (HRT) users and nonusers among colorectal cases and women without diagnosed cancer.MethodsData from the Saskatchewan Health population‐based databases were used to ascertain the use of HRT, oral contraceptives (OCs), cardiovascular system (CVS) drugs, central nervous system (CNS) drugs, prescribed NSAIDs and vitamins among 3338 women diagnosed with colorectal cancer and 13 025 women without diagnosed cancer. Physician visits and sigmoidoscopy procedures were also determined.ResultsAmong women without diagnosed cancer, HRT was associated with CVS drugs (OR=1.23, 95%CI: 1.10–1.37), CNS drugs (OR=1.96, 95%CI: 1.72–2.23), other hormones (OR=1.12, 95%CI: 1.01–1.24), prescribed vitamins (OR= 1.37, 95%CI: 1.22–1.55), NSAIDs (OR=1.41, 95%CI: 1.18–1.68), having had a sigmoidoscopy 3–5 years prior to index dates (OR=1.33, 95%CI: 1.12–1.59) and 15 or more visits to physicians during the 5th year prior to assigned index date (OR=2.0, 95%CI: 1.77–2.35). Similar results were observed among women diagnosed with colorectal cancer, but HRT use was not associated with having had a sigmoidoscopy.ConclusionsHealth‐related characteristics of HRT users and nonusers are identified and described. Some of these factors may contribute to selection bias in studies examining the health benefits of HRT. Copyright © 2003 John Wiley & Sons, Ltd.