Spatiotemporal antagonism in mesenchymal-epithelial signaling in sweat versus hair fate decision
Spatiotemporal antagonism in mesenchymal-epithelial signaling in sweat versus hair fate decision
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DOI：
10.1126/science.aah6102
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发表时间：
2016-12-23
期刊：
影响因子：
56.9
通讯作者：
Fuchs, Elaine
中科院分区：
文献类型：
--
作者：
Lu, Catherine P.;Polak, Lisa;Fuchs, Elaine
The gain of eccrine sweat glands in hairy body skin has empowered humans to run marathons and tolerate temperature extremes. Epithelial-mesenchymal cross-talk is integral to the diverse patterning of skin appendages, but the molecular events underlying their specification remain largely unknown. Using genome-wide analyses and functional studies, we show that sweat glands are specified by mesenchymal-derived bone morphogenetic proteins (BMPs) and fibroblast growth factors that signal to epithelial buds and suppress epithelial-derived sonic hedgehog (SHH) production. Conversely, hair follicles are specified when mesenchymal BMP signaling is blocked, permitting SHH production. Fate determination is confined to a critical developmental window and is regionally specified in mice. In contrast, a shift from hair to gland fates is achieved in humans when a spike in BMP silences SHH during the final embryonic wave(s) of bud morphogenesis.
