ACTION OF CARBON-DIOXIDE ON CONSTRICTED AIRWAYS
ACTION OF CARBON-DIOXIDE ON CONSTRICTED AIRWAYS
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DOI：
10.1113/jphysiol.1973.sp010407
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发表时间：
1973-01-01
影响因子：
5.5
通讯作者：
WARREN, PM
中科院分区：
文献类型：
--
作者：
ASTIN, TW;BARER, GR;WARREN, PM
1.猫狗开胸人工呼吸机中加入5-15%CO2可逆转药物或肺动脉阻断所致的支气管收缩。测量总肺阻力、静态肺顺应性以及持续泵搏时的气管或支气管内压。在给猫输注5-羟色胺(5-HT)、组胺和乙酰胆碱的过程中，二氧化碳减少了肺的阻力，增加了肺的顺应性。在狗身上，在输注5-羟色胺时，二氧化碳降低了阻力；在输注组胺和乙酰胆碱时，它使气管内压力略有降低，但阻力没有明显变化。即使在猫中，5-羟色胺对二氧化碳的影响也大于组胺和乙酰胆碱的影响。阻断一条肺动脉会导致猫和狗受影响肺叶的阻力增加和顺应性降低。高CO2混合气体的通风可部分逆转上述变化。CO2的支气管扩张作用发生在较宽的Pa值范围内(20-100托)。
1. In artificially ventilated open‐chest cats and dogs ventilation with 5–15% CO2reversed the bronchoconstriction caused by drugs or by pulmonary artery occlusion. Total lung resistance, ‘static’ lung compliance, and intratracheal or intrabronchial pressure at constant pump stroke were measured.2. CO2reduced resistance and increased compliance of the lung during infusions of 5‐hydroxytryptamine (5‐HT), histamine and acetylcholine in cats. In dogs CO2reduced resistance during 5‐HT infusions; it caused small reductions in intratracheal pressure but no significant change in resistance during infusions of histamine and acetylcholine. Even in cats CO2had a larger effect during 5‐HT than during histamine and acetylcholine infusions.3. Occlusion of a pulmonary artery caused increases in resistance and decreases in compliance in the affected lobes of both cats and dogs. These changes were partly reversed by ventilation with high CO2mixtures.4. The bronchodilator action of CO2took place over a wide range ofPa, CO2values (20–100 torr).