A CASE-CONTROL STUDY OF CORONARY HEART-DISEASE IN ATHENS, GREECE
A CASE-CONTROL STUDY OF CORONARY HEART-DISEASE IN ATHENS, GREECE
复制标题
DOI：
10.1093/ije/21.6.1074
复制
发表时间：
1992-12-01
影响因子：
7.7
通讯作者：
TRICHOPOULOS, D
中科院分区：
文献类型：
--
作者：
KALANDIDI, A;TZONOU, A;TRICHOPOULOS, D
在希腊雅典进行了一项冠心病（CHD）病例对照研究。该病例系列包括329例心电图证实的冠状动脉梗死或诊断性冠状动脉造影，或两者兼而有之，谁在16个月期间入住的主要教学医院。对照组为570例在CHD病例之前或之后因小手术、眼、耳、鼻或轻微泌尿系统问题或明确显示与CHD无关的胸部问题而入住同一医院的患者。所有病例和对照均在医院病房接受采访，并提取了选定的实验室数据。主要分析是通过多元逻辑回归建模完成的，控制人口统计学变量以及所研究风险因素的相互混杂效应。肥胖、高血压、糖尿病、血胆固醇升高和过量咖啡摄入是显著（P < 0.02）的独立危险因素，相对危险度估计值在2- 3倍范围内。吸烟和适量咖啡消费与此无显著正相关，而饮酒和经常锻炼与此无显著负相关。与下午午睡持续时间呈负相关，具有边缘统计学意义。
A case-control study of coronary heart disease (CHD) was conducted in Athens, Greece. The case series consisted of 329 patients with electrocardiographically confirmed coronary infarct or a diagnostic coronary arteriogram, or both, who were admitted during a 16-month period to a major teaching hospital. Controls were 570 patients admitted to the same hospital just before or after the CHD cases for minor surgery; eye, ear, nose or minor urological problems; or chest problems definitely shown to be unrelated to CHD. All cases and controls were interviewed in the hospital wards and selected laboratory data were abstracted. The main analysis was done by modelling through multiple logistic regression, controlling for demographic variables as well as for the mutual confounding effects of the investigated risk factors. Obesity, hypertension, diabetes mellitus, elevated blood cholesterol and excessive coffee intake were significant (P < 0.02) independent risk factors with relative risk estimates in the 2- to 3-fold range. Non-significant positive associations were found with respect to tobacco smoking and modest coffee consumption, whereas non-significant negative associations were noted with respect to alcohol intake and regular exercise. A negative association with duration of afternoon siesta was of borderline statistical significance.