Subharmonic imaging of contrast agents
Subharmonic imaging of contrast agents
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DOI：
10.1016/s0041-624x(99)00148-1
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发表时间：
2000-03-01
期刊：
影响因子：
4.2
通讯作者：
Goldberg, BB
中科院分区：
文献类型：
--
作者：
Forsberg, F;Shi, WT;Goldberg, BB
超声造影剂有望提高超声诊断成像的灵敏度和特异性。使超声设备适应于与造影剂的最佳使用是非常重要的，通过利用对比微泡的非线性特性。谐波成像是一种已被广泛研究并可在商业上获得的技术。然而，谐波成像与问题相关联，这是由于二次谐波的产生和在组织本身内的积累。考虑到组织中缺乏次谐波产生，一种替代方案是通过以基频（f（o））发射并以次谐波（f（o）/2）接收来创建次谐波图像。次谐波成像应具有更好的横向分辨率，并且由于较高的发射频率和散射的次谐波信号的小得多的衰减而可能适合于扫描深埋结构。在本文中，我们将回顾不同方面的亚谐波成像，包括实现，在体外灰度成像和亚谐波辅助压力估计。(C)2000 Elsevier Science B. V.保留所有权利。
Ultrasound contrast agents promise to improve the sensitivity and specificity of diagnostic ultrasound imaging. It is of great importance to adapt ultrasound equipment for optimal use with contrast agents e.g., by exploiting the nonlinear properties of the contrast microbubbles. Harmonic imaging is one technique that has been extensively studied and is commercially available. However, harmonic imaging is associated with problems, due to second harmonic generation and accumulation within the tissue itself. Given the lack of subharmonic generation in tissue, one alternative is the creation of subharmonic images by transmitting at the fundamental frequency (f(o)) and receiving at the subharmonic (f(o)/2). Subharmonic imaging should have a much better lateral resolution and may be suitable for scanning deep-lying structures owing to the higher transmit frequency and the much smaller attenuation of scattered subharmonic signals. Tn this paper, we will review different aspects of subharmonic imaging including implementation, in-vitro gray-scale imaging and subharmonic aided pressure estimation. (C) 2000 Elsevier Science B.V. All rights reserved.