High concentrations of interleukin-8 and monocyte chemoattractant protein-1 in urine of patients with acute Kawasaki disease
High concentrations of interleukin-8 and monocyte chemoattractant protein-1 in urine of patients with acute Kawasaki disease
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DOI：
10.1007/s00431-004-1539-1
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发表时间：
2004-12-01
影响因子：
3.6
通讯作者：
Kohno, Y
中科院分区：
文献类型：
--
作者：
Jibiki, T;Terai, M;Kohno, Y
Kawasaki disease (KD) often presents with transient urinary abnormalities such as aseptic pyuria and proteinuria during the acute phase of illness [2, 3, 5]. Freshly voided urine samples from 19 KD patients, aged 2.9±1.6 years, were available during the febrile stage and the afebrile stage after treatment with 2g/kg intravenous immune globulin over 5 days together with acetylsalicylic acid (30 mg/kg per day). For comparison, urine samples from seven patients aged 2.5±2.5 years, with congenital heart disease who did not show heart failure or urinary abnormalities were studied. During the febrile stage, 11 of 19 KD patients (58%) exhibited detectable levels of urinary interleukin-8 (IL-8)(840±855 pg/mg creatinine), whereas all controls had undetectable levels (Fig. 1a). Additionally, 7 of 19 KD patients (37%) exhibited urinary monocyte chemoattractant protein-1 (MCP-1) levels (1239±352 pg/mg creatinine) greater than 2 SD above mean control values (442±190 pg/mg creatinine)(Fig. 1b). Urinary levels of IL-8 and MCP-1 decreased significantly during the afebrile stage (P= 0.01 and P= 0.01, respectively)(Fig. 1a,
