Consumption of long-chain n-3 PUFA, α-linolenic acid and fish is associated with the prevalence of chronic kidney disease
Consumption of long-chain n-3 PUFA, α-linolenic acid and fish is associated with the prevalence of chronic kidney disease
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DOI：
10.1017/s0007114510005040
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发表时间：
2011-05-01
影响因子：
3.6
通讯作者：
Mitchell, Paul
中科院分区：
文献类型：
--
作者：
Gopinath, Bamini;Harris, David C.;Mitchell, Paul
由于PUFA的抗炎特性，有人认为它们可以保护成年人免受肾损伤。然而，相对较少的流行病学研究在人类受试者中检验了这一假设。我们调查了膳食中多不饱和脂肪酸（n-3，n-6和α-亚麻酸）、鱼类摄入量与慢性肾脏病（CKD）患病率之间的关系。共分析了2600名年龄≥ 50岁的蓝山眼科研究（1997-9）参与者。膳食数据收集使用半定量FFQ，多不饱和脂肪酸和鱼类摄入量进行了计算。测量基线生化，包括血清肌酐。中度CKD定义为估计的肾小球滤过率
Due to the anti-inflammatory properties of PUFA, it has been suggested that they may protect against kidney damage in adults. However, relatively few epidemiological studies have examined this hypothesis in human subjects. We investigated the association between dietary intakes of PUFA (n-3, n-6 and alpha-linolenic acid), fish and the prevalence of chronic kidney disease (CKD). A total of 2600 Blue Mountains Eye Study (1997-9) participants aged >= 50 years were analysed. Dietary data were collected using a semi-quantitative FFQ, and PUFA and fish intakes were calculated. Baseline biochemistry including serum creatinine was measured. Moderate CKD was defined as an estimated glomerular filtration rate of