Fumiquinones A and B, nematicidal quinones produced by Aspergillus fumigatus
Fumiquinones A and B, nematicidal quinones produced by Aspergillus fumigatus
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DOI：
10.1271/bbb.70110
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发表时间：
2007-07-01
影响因子：
1.6
通讯作者：
Kimura, Yasuo
中科院分区：
文献类型：
--
作者：
Hayashi, Asami;Fujioka, Shozo;Kimura, Yasuo
从烟曲霉（Aspergillusfumigatus）中分离得到新的杀线虫剂烟醌A（1）和B（2），以及spinulosin（3），LL-S490 beta（4）和pseurotin A（5），并通过光谱方法（包括2D-NMR）确定了它们的结构。化合物1对松材线虫和短体线虫表现出有效的杀线虫活性，除莴苣幼苗外，不抑制植物生长。化合物2对B具有较好的杀线虫活性。对木霉菌的抑制活性，但对木霉菌无抑制活性。化合物3-5对B具有较好的杀线虫活性。没有任何植物生长抑制。化合物1-5对秀丽隐杆线虫无杀线虫活性。这是首次报道化合物3-5的杀线虫活性。
New nematicides named fumiquinones A (1) and B (2), together with spinulosin (3), LL-S490 beta (4), and pseurotin A (5), were isolated from Aspergillus fumigatus and their structures were established by spectroscopic methods including 2D-NMR. Compound 1 showed effective nematicidal activities against Bursaphelenchus xylophilus and Pratylenchus penetrans,without inhibiting plant growth except for lettuce seedlings. Compound 2 showed effective nematicidal activity against B. xylophilus, but had no inhibitory activity against P. penetrans. Compounds 3-5 showed effective nematicidal activities against B. xylophilus without any plant growth inhibition. Compounds 1-5 had no nematieidal activity against Caenorhabditis elegans. This is the first report of the nematicidal activities of compounds 3-5.