Rheumatoid arthritis and periodontitis; a possible link via citrullination
Rheumatoid arthritis and periodontitis; a possible link via citrullination
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DOI：
10.1016/j.anaerobe.2011.03.019
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发表时间：
2011-08-01
期刊：
影响因子：
2.3
通讯作者：
van Winkelhoff, A. J.
中科院分区：
文献类型：
--
作者：
de Smit, M. J.;Brouwer, E.;van Winkelhoff, A. J.
类风湿性关节炎(RA)和慢性侵袭性牙周炎是一种慢性炎症性疾病，其特征是宿主炎症反应失控。促炎介质的分泌增加会分别导致滑膜和牙周组织的软组织和硬组织破坏。这两种疾病都有共同的危险因素和共同的病理途径，导致最终的临床结果是功能丧失和残疾。这篇文章讨论了可能的相互作用，特别是与牙周病原体牙龈卟啉单胞菌相关的，这可以解释这两种流行疾病之间的观察到的联系。(C)2011爱思唯尔有限公司。保留所有权利。
Rheumatoid Arthritis (RA) and chronic and aggressive periodontitis are chronic inflammatory disorders characterized by deregulation of the host inflammatory response. Increased secretion of pro-inflammatory mediators results in soft and hard tissue destruction of the synovium and periodontium respectively. Both diseases share risk factors and have pathological pathways in common, resulting in loss of function and disability as a final clinical outcome. This article discusses possible interactions, particularly related to the periodontal pathogen Porphyromonas gingivalis, which could explain the observed association between these two prevalent diseases. (C) 2011 Elsevier Ltd. All rights reserved.