Alcohol-induced testicular atrophy in the adult male rat.
Alcohol-induced testicular atrophy in the adult male rat.
复制标题
酒精引起的成年雄性大鼠睾丸萎缩。
DOI：
10.1210/endo-105-4-888
复制
发表时间：
1979
期刊：
影响因子：
4.8
通讯作者：
Roger Lester
中科院分区：
文献类型：
--
作者：
D. Thiel;Judith S. Gavaler;C. F. Cobb;R. J. Sherins;Roger Lester
本文研究了酒精喂养对成年雄性大鼠睾丸功能和结构的影响，实验动物为酒精喂养组、等热量喂养对照组和体重饥饿对照组。与对照组相比，酒精喂养的动物的睾丸重量减轻了50%以上。与对照组相比，饮酒组大鼠的睾丸组织学外观有明显的破坏。具体地说，生精小管平均直径(P<；0.01)和含有生殖细胞的数量(P<；0.01)显著减少。与两个对照组中的任何一个相比，酒精喂养的动物的血浆睾酮水平(P<；0.01)都降低了。相反，与等卡路里对照组相比，酒精喂养和体重饥饿的动物的血浆雌二醇水平降低(P<；0.05)。酒精喂养的动物血浆FSH水平是对照组的两倍(P<；0.01)，而不同组间的血浆促黄体生成素水平没有差异。AC..。
The effect of ethanol feeding on testicular function and structure in adult male rats was studied in alcohol-fed animals, isocalorically fed controls, and weight-starved controls. Testicular weight was reduced by more than 50% in alcohol-fed animals compared to the control groups. Marked disruption of the histological appearance of the testes was observed in the alcohol-fed animals when compared to the controls. Specifically, there was prominent reduction in the mean seminiferous tubule diameter (P < 0.01) and number of contained germ cells (P < 0.01). Plasma levels of testosterone (P < 0.01) were reduced in the alcohol-fed animals when compared to either of the two control groups. In contrast, plasma estradiol levels were reduced in the alcohol-fed and weight-starved animals when compared to those of the isocaloric controls {P < 0.05). Plasma FSH levels in the alcohol-fed animals were twice those of the controls (P < 0.01), while no difference in plasma LH levels was observed among the various groups. Ac...