The SF3b complex: splicing and beyond
The SF3b complex: splicing and beyond
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DOI：
10.1007/s00018-020-03493-z
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Chengfu Sun
中科院分区：
文献类型：
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作者：
Chengfu Sun
The SF3b complex is an intrinsic component of the functional U2 small nuclear ribonucleoprotein (snRNP). As U2 snRNP enters nuclear pre-mRNA splicing, SF3b plays key roles in recognizing the branch point sequence (BPS) and facilitating spliceosome assembly and activation. Since the discovery of SF3b, substantial progress has been made in elucidating its molecular mechanism during splicing. In addition, numerous recent studies indicate that SF3b and its components are engaged in various molecular and cellular events that are beyond the canonical role in splicing. This review summarizes the current knowledge on the SF3b complex and highlights its multiple roles in splicing and beyond.
