Flualprazolam Blood Concentrations in 197 Forensic Investigation Cases
Flualprazolam Blood Concentrations in 197 Forensic Investigation Cases
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DOI：
10.1093/jat/bkaa070
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发表时间：
2021-04-01
影响因子：
2.5
通讯作者：
Logan, Barry K.
中科院分区：
文献类型：
--
作者：
Papsun, Donna M.;Krotulski, Alex J.;Logan, Barry K.
氟拉唑仑是一种设计苯二氮卓类药物和新型精神活性物质，在法医调查中日益流行和出现。在2019年8月至2020年2月期间报告的法医死亡调查和人体表现病例的197份血液样本中，定量确认了氟唑安定。采用液相色谱-飞行时间质谱法进行药物筛选，采用液相色谱-串联质谱法进行定量确认。在没有可用的传统验证分析的情况下，实施了三点标准添加方案进行定量。在有定量结果的死后病例中（n = 167），氟唑仑的平均（±标准差[SD]）浓度为20 (+/- 63)ng/mL，中位浓度为8.2 ng/mL，浓度范围为2.0 ~ 620 ng/mL。另有四宗死后病例报告呈阳性(
Flualprazolam is a designer benzodiazepine and novel psychoactive substance that is increasing in prevalence and appearing in forensic investigations. Flualprazolam was quantitatively confirmed in 197 blood samples from medicolegal death investigations and human performance cases reported between August 2019 and February 2020. Drug screening was performed using liquid chromatography-time-of-flight mass spectrometry and quantitative confirmation was performed using liquid chromatography-tandem mass spectrometry. A three-point standard addition protocol was implemented for quantitation in the absence of an available traditionally validated assay. In postmortem cases with quantitative results (n = 167), the mean (+/- standard deviation [SD]) flualprazolam concentration was 20 (+/- 63) ng/mL, the median concentration was 8.2 ng/mL and the range of concentrations was 2.0-620 ng/mL. Four additional postmortem cases were reported positive (