Neuregulins 1-4 are expressed in the cytoplasm or nuclei of ductal carcinoma (in situ) of the human breast
Neuregulins 1-4 are expressed in the cytoplasm or nuclei of ductal carcinoma (in situ) of the human breast
复制标题
DOI：
10.1007/s10549-005-9073-z
复制
发表时间：
2006-03-01
影响因子：
3.8
通讯作者：
Gullick, William J.
中科院分区：
文献类型：
--
作者：
Marshall, Catherine;Blackburn, Edith;Gullick, William J.
最近发现了一个新的表皮生长因子样蛋白家族——神经调节蛋白（NRG），并在一系列正常组织和包括乳腺癌在内的某些形式的癌症中表达。在本研究中，我们使用免疫组织化学染色检查了代表不同分化程度的 60 例乳腺浸润前导管原位癌中 NRG1 α、NRG1 β、NRG2 α、NRG2 β、NRG3 和 NRG4 的表达。每种蛋白质在这些病例中表达的比例很高，显示出主要同质的细胞质染色模式。然而，在相当一部分病例中也观察到 NRG1 α、NRG1 β 和 NRG3 的核表达。 NRG2 β 和 NRG4 的高水平表达与高级别肿瘤相关 (p 25 mm (p = 0.005)，而 NRG3 核染色更常见于低级别肿瘤 (p = 0.039)。该数据表明，NRG 配体家族的每个成员都存在于浸润前导管乳腺癌中，并且它们可能参与调节细胞行为。核内表达的重要性仍然在于 尚未确定，但提出了其中一些蛋白质的新作用机制。
A new family of epidermal growth factor-like proteins, the Neuregulins (NRGs), have recently been identified and are expressed in a range of normal tissues and in some forms of cancer including breast cancer. In this study we examined using immunohistochemical staining expression of NRG1 alpha, NRG1 beta, NRG2 alpha, NRG2 beta, NRG3 and NRG4 in sixty cases of pre-invasive ductal carcinoma in situ of the breast representing different degrees of differentiation. Each protein was expressed in a high proportion of these cases showing a predominantly homogenous cytoplasmic staining pattern. Nuclear expression or NRG1 alpha, NRG1 beta, and NRG3 was however also observed in a significant fraction of cases. High levels of expression of NRG2 beta and NRG4 were associated with high-grade tumours (p 25 mm (p = 0.005) while NRG3 nuclear staining was present more often in low-grade tumours (p = 0.039). This data demonstrates that each member of the NRG family of ligands is present in pre-invasive ductal breast cancer and that they may be involved in regulating cell behaviour. The significance of intranuclear expression remains to be determined but suggests a novel mechanism of action for some of these proteins.