Regulation of Metabolic Pathways by MarR Family Transcription Factors.
Regulation of Metabolic Pathways by MarR Family Transcription Factors.
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DOI：
10.1016/j.csbj.2017.06.001
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发表时间：
2017
影响因子：
6
通讯作者：
Grove A
中科院分区：
文献类型：
--
作者：
Grove A
细菌已经进化出复杂的代谢途径调节机制。这种调节回路确保合成代谢途径保持被抑制，除非最终产物供应不足，并且在缺乏其底物的情况下不产生分解代谢酶。这种回路背后的精确调节的基因活性属于转录因子的范围，这些转录因子可以结合途径中间体，进而调节转录因子功能并因此调节基因表达。本文综述了配体反应性马尔R家族转录因子在调控代谢酶基因表达中的作用及其调控机制。展望利用这些转录因子的优化基因表达的代谢工程和生物传感器的发展。
Bacteria have evolved sophisticated mechanisms for regulation of metabolic pathways. Such regulatory circuits ensure that anabolic pathways remain repressed unless final products are in short supply and that catabolic enzymes are not produced in absence of their substrates. The precisely tuned gene activity underlying such circuits is in the purview of transcription factors that may bind pathway intermediates, which in turn modulate transcription factor function and therefore gene expression. This review focuses on the role of ligand-responsive MarR family transcription factors in controlling expression of genes encoding metabolic enzymes and the mechanisms by which such control is exerted. Prospects for exploiting these transcription factors for optimization of gene expression for metabolic engineering and for the development of biosensors are considered.