Transfusion-transmitted hepatitis E in a 'nonhyperendemic' country
Transfusion-transmitted hepatitis E in a 'nonhyperendemic' country
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DOI：
10.1111/j.1365-3148.2006.00652.x
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发表时间：
2006-04-01
影响因子：
1.5
通讯作者：
Teo, CG
中科院分区：
文献类型：
--
作者：
Boxall, E;Herborn, A;Teo, CG
在发达国家，本土戊型肝炎得到越来越多的承认，在那里它可能是一种人畜共患病。我们描述了英国第一例输血传播的戊型肝炎病例，其献血者最近没有出国旅行的历史。采用血清学和分子技术对献血者和受血者进行随访。急性戊型肝炎传播给两个受血者中的一个。被感染的患者会收到更大体积的捐赠者的血浆。供受者携带的HEV亚基因组序列相同，这是英国首例输血后戊型肝炎病例。非高流行国家本土的戊型肝炎的继发性传播可能通过输血发生。重要的是，献血者应将所有献血后疾病告知输血服务机构，以便采取适当的干预措施。
Indigenous hepatitis E is increasingly recognized in developed countries, where it may be a zoonosis. We describe the first case of transfusion-transmitted hepatitis E in the UK from a blood donor who had no history of recent travel abroad.Follow-up of the donor and recipients of the blood products was carried out using serological and molecular techniques.Acute hepatitis E was transmitted to one of two recipients. The infected patient would have received a larger volume of the donor's plasma. HEV subgenomic sequences carried by the donor and recipient were identical.This is the first case of post-transfusion hepatitis E in the UK. Secondary transmission of hepatitis E indigenous to a nonhyperendemic country may occur by blood transfusion. It is important that blood donors inform the transfusion service of all post-donation illnesses so that appropriate interventions can take place.