More evidence of cardiorenal protective effects of peroxisome proliferator-activated receptor activation.
More evidence of cardiorenal protective effects of peroxisome proliferator-activated receptor activation.
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更多证据表明过氧化物酶体增殖物激活受体激活对心肾有保护作用。
作者：
E. Schiffrin
过氧化物酶体增殖体激活受体（ppar）是一种与类视黄酮X受体异二聚的核受体，可调节多种靶基因的功能。三种ppar， α， β/δ和γ已被证实。PPARα参与脂肪酸氧化并在肝、肾和骨骼肌中表达；PPARβ/δ普遍存在并调节脂质代谢；PPARγ在脂肪细胞分化、脂质储存和胰岛素敏感性中发挥作用ppar存在于心血管组织中，包括内皮细胞、平滑肌细胞、巨噬细胞和心脏。2-4贝特类（降血脂剂）和脂肪酸激活PPARα，噻唑烷二酮类或格列酮类（降糖药）刺激ppar γ然而，PPARs的内源性配体仍然未知。
Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors that heterodimerize with the retinoid X receptor and modulate functions of many target genes. Three PPARs, α, β/δ, and γ, have been demonstrated. PPARα is involved in fatty acid oxidation and expressed in liver, kidney, and skeletal muscle; PPARβ/δ is ubiquitous and regulates lipid metabolism; and PPARγ plays a role in fat cell differentiation, lipid storage, and insulin sensitivity.1 PPARs are present in cardiovascular tissues, including the endothelium, smooth muscle cells, macrophages, and the heart.2–4 Fibrates (hypolipemic agents) and fatty acids activate PPARα, and thiazolidinediones or glitazones (antidiabetic drugs) stimulate PPARγ.5 However, the endogenous ligands of PPARs remain unknown.
PPARα and PPARγ have increasingly been demonstrated to exert cardiovascular protective effects, independent of their metabolic actions.3,4 Whereas metabolic effects of PPARs are mediated by activation of a PPAR-responsive element present in the promoter region of different genes, the cardiovascular protective actions may result from anti-inflammatory and antioxidant actions mediated by transrepression of proinflammatory and pro-oxidant …
影响因子：
20.1
作者：
MA, YH;GEBREMEDHIN, D;ROMAN, RJ
通讯作者：
ROMAN, RJ