Phase II study of platinum and mitoxantrone in metastatic prostate cancer: a Southwest Oncology Group Study.

Phase II study of platinum and mitoxantrone in metastatic prostate cancer: a Southwest Oncology Group Study.
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铂和米托蒽醌治疗转移性前列腺癌的 II 期研究:西南肿瘤小组研究。

DOI:
10.1016/s0959-8049(05)80080-2
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发表时间:
1992
期刊:
European journal of cancer (Oxford, England : 1990)
影响因子:
--
通讯作者:
Larrimer,NR
Larrimer,NR
中科院分区:
--
文献类型:
--
作者:
Osborne,CK;Blumenstein,BA;Crawford,ED;Weiss,GR;Bukowski,RM;Larrimer,NR

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44 eligible patients with measurable or evaluable metastatic prostate cancer were treated with monthly cycles of cisplatin and mitoxantrone. Good-risk patients received cisplatin 60 mg/m2intravenously and mitoxantrone 10 mg/m2intravenously every 4 weeks. The dose in poor-risk patients (elderly or white blood cell count < 4000/μl, 4 × 109/1, or extensive prior radiation) was reduced to 8 mg/m2. Toxicity was manageable and consisted primarily of myelosuppression. There were no complete responses and the partial response rate was only 12%. Median progression-free survival was 2.7 months for measurable and 4.1 months for evaluable disease patients. Median survivals were 4.9 and 8.7 months, respectively. This combination has minimal activity in hormone refractory metastatic prostate cancer.
在盆腔或腰骶部接受过广泛照射的晚期激素难治性前列腺癌患者中,磷酸雌莫司汀与单独顺铂与磷酸雌莫司汀加顺铂的比较。
DOI: 10.1016/s0022-5347(17)51917-5
发表时间: 1983
期刊: The Journal of urology
影响因子: --
作者:
M. Soloway;S. Beckley;M. Brady;T. Chu;J. Dekernion;C. Dhabuwala;J. Gaeta;R. Gibbons;S. Loening;C. McKiel;D. Mcleod;J. Pontes;G. Prout;P. Scardino;J. Schlegel;Joseph D. Schmidt;W. Scott;N. Slack;G. Murphy
通讯作者: G. Murphy
米托蒽醌和阿米坦醌对小鼠肿瘤的治疗活性。
DOI: 10.1016/0305-7372(83)90017-8
发表时间: 1983
影响因子: 11.8
作者:
F. Schabel;T. Corbett;D. Griswold;W. R. Laster;M. W. Trader
通讯作者: M. W. Trader
使用顺式二氯二氨铂输注治疗晚期前列腺癌(D 期)(II NSC 119875):一项试点研究。
DOI: 10.1016/s0022-5347(17)57535-7
发表时间: 1978
期刊: The Journal of urology
影响因子: --
作者:
C. Merrin
通讯作者: C. Merrin
米托蒽醌:在晚期前列腺癌的 II 期试验中具有适度的活性。
DOI: --
发表时间: 1983
期刊: Cancer treatment reports
影响因子: --
作者:
Osborne,CK;Drelichman,A;VonHoff,DD;Crawford,ED
通讯作者: Crawford,ED
DOI: --
发表时间: 1980
影响因子: 39.2
作者:
F. Torti;S. Carter
通讯作者: S. Carter