Excess haemoglobin digestion by malaria parasites: a strategy to prevent premature host cell lysis
Excess haemoglobin digestion by malaria parasites: a strategy to prevent premature host cell lysis
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DOI：
10.1016/j.bcmd.2004.01.006
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发表时间：
2004-05-01
影响因子：
2.3
通讯作者：
Tiffert, T
中科院分区：
文献类型：
--
作者：
Lew, VL;Macdonald, L;Tiffert, T
为了了解恶性疟原虫感染的红细胞的渗透稳定性，其膜渗透性在寄生虫生长期间变得高度增加，我们开发了一个受感染的红细胞的稳态的综合数学模型。该模型编码的红细胞膜透化和血红蛋白消化，以及寄生虫体积增长的替代方案的已知时间过程。模型模拟表明，过量的血红蛋白消化，通过降低宿主红细胞内的胶体渗透压，是必不可少的寄生虫无性周期的持续时间内保持感染细胞的渗透稳定性。我们在这里提出的模型预测的实验测试，并讨论了现有的证据的背景下，由模型提供的解释。(C)2004年爱思唯尔公司All rights reserved.
To understand the osmotic stability of a Plasmodium falciparum-infected red blood cell, whose membrane permeability becomes highly increased during parasite growth, we developed an integrated mathematical model of the homeostasis of an infected red cell. The model encoded the known time courses of red cell membrane permeabilisation and of haemoglobin digestion, as well as alternative options for parasite volume growth. Model simulations revealed that excess haemoglobin digestion, by reducing the colloid-osmotic pressure within the host red cell, is essential to preserve the osmotic stability of the infected cell for the duration of the parasite asexual cycle. We present here experimental tests of the model predictions and discuss the available evidence in the context of the interpretations provided by the model. (C) 2004 Elsevier Inc. All rights reserved.