The higher level of organization of the oxidative phosphorylation system: mitochondrial supercomplexes.
The higher level of organization of the oxidative phosphorylation system: mitochondrial supercomplexes.
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DOI：
10.1007/s10863-008-9167-5
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发表时间：
2008-10
影响因子：
3
通讯作者：
Braun, Hans-Peter
中科院分区：
文献类型：
--
作者：
Dudkina, Natalya V.;Sunderhaus, Stephanie;Boekema, Egbert J.;Braun, Hans-Peter
The organization of the oxidative phosphorylation (OXPHOS) system within the inner mitochondrial membrane appears to be far more complicated than previously thought. In particular, the individual protein complexes of the OXPHOS system (complexes I to V) were found to specifically interact forming defined supramolecular structures. Blue-native polyacrylamide gel electrophoresis and single particle electron microscopy proved to be especially valuable in studying the so-called “respiratory supercomplexes”? Based on these procedures, increasing evidence was presented supporting a “solid state” organization of the OXPHOS system. Here, we summarize results on the formation, organisation and function of the various types of mitochondrial OXPHOS supercomplexes.
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