Comparison of Quantitative Cerebral Blood Flow Measurements Performed by Bookend Dynamic Susceptibility Contrast and Arterial Spin-Labeling MRI in Relapsing-Remitting Multiple Sclerosis.
Comparison of Quantitative Cerebral Blood Flow Measurements Performed by Bookend Dynamic Susceptibility Contrast and Arterial Spin-Labeling MRI in Relapsing-Remitting Multiple Sclerosis.
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DOI：
10.3174/ajnr.a4939
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发表时间：
2016-12
期刊：
影响因子：
--
通讯作者：
Aviv RI
中科院分区：
文献类型：
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作者：
D'Ortenzio RM;Hojjat SP;Vitorino R;Cantrell CG;Lee L;Feinstein A;O'Connor P;Carroll TJ;Aviv RI
定量CBF作为MS中认知障碍和疾病进展的生物标志物的使用可能是纵向患者监测的有力工具。使用Bookend T1校准的动态磁敏感对比灌注（书端技术）和伪连续动脉自旋标记最近已用于复发-缓解型MS中的CBF定量。伪连续动脉自旋标记的非侵入性性质优于基于钆的技术，但是在MS的背景下，这些技术之间的相关性还没有很好地建立。在19名健康对照、19名无认知障碍的复发缓解型MS受试者和20名有认知障碍的复发缓解型MS受试者的前瞻性队列中，在体素和Brodmann区域基础上，使用连续动脉自旋标记CBF到Bookend技术。线性皮尔逊相关，信噪比和变异系数进行量化。体素配对T检验显示，在全球平均强度标准化后，技术之间的CBF没有显着差异。在深部GM结构中观察到最高的Pearson相关性（平均r = 0.71基底神经节和r = 0.65丘脑），但对于皮质GM、WM和WML保持稳健（平均r分别为0.51、0.53、0.54）。CL的Pearson相关性较低（平均r=0.23）。Brodmann区域相关性在所有组中均显著。所有相关性在健康对照组和RRMS疾病中均保持不变。最高的SNR存在于Bookend灌注，而最高的变异系数存在于WML。在健康对照组和复发缓解型MS患者中证实了伪连续动脉自旋标记和Bookend技术CBF测量之间的一致性
Quantitative CBF usage as a biomarker for cognitive impairment and disease progression in MS is potentially a powerful tool for longitudinal patient monitoring. Dynamic Susceptibility contrast perfusion with Bookend T1-calibration (Bookend Technique) and pseudo-continuous Arterial Spin Labeling have recently been used for CBF quantification in relapsing-remitting MS. The non-invasive nature of pseudo-continuous Arterial Spin Labeling is advantageous over gadolinium-based techniques, but correlation between the techniques is not well established in the context of MS. We compared pseudo-continuous Arterial Spin Labeling CBF to the Bookend technique in a prospective cohort of 19 healthy controls, 19 relapsing-remitting MS subjects without cognitive impairment and 20 relapsing-remitting MS subjects with cognitive impairment on a voxel-wise and Brodmann regional basis. Linear Pearson correlation, SNR and coefficient of variation were quantified. Voxel-wise paired T-tests revealed no significant CBF differences between techniques after normalization of global mean intensities. Highest Pearson correlations were observed in deep GM structures (average r = 0.71 basal ganglia, and r = 0.65 thalamus) but remained robust for cortical GM, WM and WML (average r = 0.51, 0.53, 0.54 respectively). Lower Pearson correlations were observed for CL (average r=0.23). Brodmann regional correlations were significant for all groups. All correlations were maintained in healthy controls and in RRMS disease. Highest SNR was present in Bookend perfusion while the highest coefficient of variation was present in WML. Agreement between pseudo-continuous Arterial Spin Labeling and Bookend technique CBF measurements is demonstrated in healthy controls and relapsing-remitting MS patients