Sialic acid levels in breast milk from HIV-positive Tanzanian women and impact of maternal diet.
Sialic acid levels in breast milk from HIV-positive Tanzanian women and impact of maternal diet.
复制标题
艾滋病毒呈阳性的坦桑尼亚妇女母乳中的唾液酸水平以及母亲饮食的影响。
DOI：
10.1097/qad.0000000000002081
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发表时间：
2019
期刊：
影响因子：
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通讯作者：
VonReyn,CFord
中科院分区：
文献类型：
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作者：
Connor,RuthI;Zain-Ul-Abideen,Muhammad;Magohe,AlbertK;Brickley,ElizabethB;Housman,MollyL;Lyimo,MagdalenaA;Mchaki,Betty;Maro,Isaac;Hendricks,KristyM;Lukmanji,Zohra;Matee,Mecky;Bakari,Muhammad;Pallangyo,Kisali;VonReyn,CFord
Objective:To quantify total sialic acid in milk from HIV-positive Tanzanian mothers and to determine the impact of maternal diet on milk sialic acid levels.Design:Milk samples were analyzed from 74 HIV-positive, Tanzanian women enrolled in a randomized, controlled clinical study of a dietary macronutrient supplement. Women were provided with a daily protein–calorie supplement and a micronutrient supplement or micronutrient supplement only during the last trimester of pregnancy and up to the first 6 months of breastfeeding.Methods:Milk samples were collected at approximately 2 weeks and at least 3 months postpartum and assayed for total sialic acid. Milk sialic acid was assessed relative to maternal macronutrient intake, age, BMI, CD4+ cell count and infant birth weight.Results:The mean concentration of milk sialic acid was highest in the first 2 weeks postpartum (6.89±2.79 mmol/l) and declined rapidly by 3 months (2.49±0.60 mmol/l). Sialic acid content in milk was similar between both treatment arms of the study, and did not correlate with maternal macronutrient intake. No correlation was found between maternal age, BMI, CD4+ cell count or infant birth weight and total milk sialic acid concentration.Conclusion:Milk sialic acid levels in HIV-positive, Tanzanian women without malnutrition are comparable with reported values for women of European descent and show a similar temporal decline during early lactation. These findings suggest that total milk sialic acid is maintained despite macronutrient deficiencies in maternal diet and support a conserved role for milk sialic acid in neonatal development.
