New Era of Cell-Based Orthopedic Therapies
New Era of Cell-Based Orthopedic Therapies
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DOI：
10.1089/ten.teb.2008.0515
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发表时间：
2009-06-01
影响因子：
6.4
通讯作者：
Caplan, Arnold I.
中科院分区：
文献类型：
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作者：
Caplan, Arnold I.
长期以来，关于间充质干细胞（MSC）的胚胎形成和它们的成体修复和再生动力学，在骨和其他骨骼组织的方面，一直描述间充质干细胞（MSC）和血管之间的关系。使用外源性添加的MSC来补充天然可用的祖细胞储备已经是通过将骨髓添加到修复结构中的几种骨科手术中的标准实践。这一点，再加上对血管系统定向和驱动骨形成的明确需求，牢固地建立了MSC、骨祖细胞和血管之间的功能关系。现在很明显，MSC是遍布全身的周细胞（包围血管的细胞）。此外，MSC可以分泌具有免疫调节作用的生物活性因子，从而允许将同种异体MSC输注到需要临床相关治疗的患者中。这种输注的MSC营养性地建立支持损伤组织再生的微环境。这些新功能开创了基于细胞疗法的新时代。
There has long been a described relationship between mesenchymal stem cells (MSCs) and blood vessels in aspects of bone and other skeletal tissues with regard to their embryonic formation and their adult repair and regeneration dynamics. The use of exogenously added MSCs to supplement the naturally available progenitor cell stock has been a standard practice in several orthopedic surgeries by adding bone marrow to the repair constructs. This, coupled with the well-established need for vasculature to orient and drive bone formation, firmly established the functional relationship between MSCs, osteoprogenitors, and blood vessels. It is now apparent that MSCs are pericytes (cells that surround blood vessels) throughout the body. In addition, MSCs can function to secrete bioactive factors that are immunomodulatory, thus allowing allogeneic MSCs to be infused into patients requiring clinically relevant treatments. Such infused MSCs trophically establish microenvironments that support the regeneration of the injured tissue. These new functions usher in a new era of cell-based therapies.