Prognostic Value of Early Evaluation of Left Ventricular Dyssynchrony After Myocardial Infarction
Prognostic Value of Early Evaluation of Left Ventricular Dyssynchrony After Myocardial Infarction
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DOI：
10.1007/s11307-018-1279-7
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发表时间：
2019-08-01
影响因子：
3.1
通讯作者：
Kinuya, Seigo
中科院分区：
文献类型：
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作者：
Wakabayashi, Hiroshi;Taki, Junichi;Kinuya, Seigo
目的：在心肌梗死（MI）后不同严重程度的心室系统中，经常观察到正常协调的心室系统收缩中的离散度，即左室（LV）非同步化。我们的目的是利用定量门控单光子发射断层扫描（SPECT； QGS）软件研究大鼠心肌梗死后不良心脏事件早期非同步化的预后价值。16只大鼠开胸后左冠状动脉闭塞再灌注。MI后3天、1周、2周、4周、8周用[(99m) Tc]甲氧基异丁基异腈进行SPECT。采用QGS软件分析相分析参数，包括平均相标准差（PSD）、带宽（BW）、熵和LV函数。采用受试者工作特征曲线探讨心源性死亡和严重心力衰竭（射血分数[EF]）的预测因子。
PurposeDispersion in the contraction of the normally coordinate ventricular system, referred to as left ventricular (LV) dyssynchrony, is constantly observed at different grades of severity after myocardial infarction (MI). We aimed to investigate the prognostic value of early dyssynchrony in adverse cardiac events after MI in a rat model using the quantified gated single photon emission tomography (SPECT; QGS) software.ProceduresAfter thoracotomy, the left coronary arteries of 16 rats were occluded and reperfused. SPECT was performed with [(99m) Tc]methoxyisobutylisonitrile 3days, 1week, 2weeks, 4weeks, and 8weeks after MI. The phase analysis parameters including mean phase standard deviation (PSD), bandwidth (BW), entropy, and LV function were analyzed by the QGS software. A receiver operating characteristic curve was used to explore the predictors for cardiac death and severe cardiac failure (ejection fraction [EF]