THE MEC-4 GENE IS A MEMBER OF A FAMILY OF CAENORHABDITIS-ELEGANS GENES THAT CAN MUTATE TO INDUCE NEURONAL DEGENERATION
THE MEC-4 GENE IS A MEMBER OF A FAMILY OF CAENORHABDITIS-ELEGANS GENES THAT CAN MUTATE TO INDUCE NEURONAL DEGENERATION
复制标题
DOI：
10.1038/349588a0
复制
发表时间：
1991-02-14
期刊：
影响因子：
64.8
通讯作者：
CHALFIE, M
中科院分区：
文献类型：
--
作者：
DRISCOLL, M;CHALFIE, M
mec-4（机械感觉所需的基因）的三个显性突变导致秀丽隐杆线虫的触觉感受器神经元退化。 mec-4 与 deg-1（另一个可以突变以诱导神经元变性且序列相似的线虫基因）一起定义了一个新的基因家族。 在其他物种中可以检测到交叉杂交序列，这增加了其他生物体中的退化状况可能是由相似基因的突变引起的可能性。 所有三种显性 mec-4 突变均影响相同的氨基酸。 该位置的氨基酸取代的影响表明空间位阻可能诱导退化状态。
Three dominant mutations of mec-4, a gene needed for mechanosensation, cause the touch-receptor neurons of Caenorhabditis elegans to degenerate. With deg-1, another C. elegans gene that can mutate to induce neuronal degeneration and that is similar in sequence, mec-4 defines a new gene family. Cross-hybridizing sequences are detectable in other species, raising the possibility that degenerative conditions in other organisms may be caused by mutations in similar genes. All three dominant mec-4 mutations affect the same amino acid. Effects of amino-acid substitutions at this position suggest that steric hindrance may induce the degenerative state.