Eye dominance columns from an isogenic double-nasal frog eye.
Eye dominance columns from an isogenic double-nasal frog eye.
复制标题
来自同基因双鼻蛙眼的眼睛优势柱。
DOI：
10.1126/science.6857287
复制
发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Meyer,RL
中科院分区：
文献类型：
--
作者：
Ide,CF;Fraser,SE;Meyer,RL
切除Xenopus眼芽后部（颞部）三分之二的部分会产生一个剩余的碎片，它会变圆并长到正常成人大小的眼睛。电生理和解剖学分析表明，这只眼睛的两个半投射在整个视顶盖的镜像（双鼻）的方式，从每个半眼的纤维整理，形成眼优势条纹顶盖。镜像对称图的两个半部分仅来自一只动物，并且仅来自头部的一侧，排除了导致这些条纹形成的全局标记，例如左右和组织相容性差异。
Removing the posterior (temporal) two-thirds of theXenopuseye bud produces a remaining fragment, which becomes round and grows to a normal adult size eye. Electrophysiological and anatomical analyses showed that each of the two halves of this eye projected across the entire optic tectum in mirror image (double-nasal) fashion, and that fibers from each half-eye sorted out to form eye dominance stripes on the tectum. That both halves of the mirror-symmetric map were derived from only one animal, and from only one side of the head, rules out global markers such as right versus left and histocompatibility differences as causing the formation of these stripes.