The sox family of transcription factors: versatile regulators of stem and progenitor cell fate.
The sox family of transcription factors: versatile regulators of stem and progenitor cell fate.
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DOI：
10.1016/j.stem.2012.12.007
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发表时间：
2013-01-03
期刊：
影响因子：
23.9
通讯作者：
Hochedlinger, Konrad
中科院分区：
文献类型：
--
作者：
Sarkar, Abby;Hochedlinger, Konrad
Sox家族转录因子是发育过程中细胞命运决定的公认调节因子。越来越多的证据表明，它们在成人组织的稳态和再生中发挥着额外的作用。值得注意的是，Sox因子的强制表达与其他协同因子相结合，将分化的细胞重新编程为体细胞或多能干细胞。Sox因子的失调进一步涉及包括癌症在内的疾病。在这里，我们回顾了Sox蛋白与干细胞生物学，细胞重编程和疾病的分子和功能证据，重点是Sox2。
The Sox family of transcription factors are well-established regulators of cell fate decisions during development. Accumulating evidence documents that they play additional roles in adult tissue homeostasis and regeneration. Remarkably, forced expression of Sox factors, in combination with other synergistic factors, reprograms differentiated cells into somatic or pluripotent stem cells. Dysregulation of Sox factors has been further implicated in diseases including cancer. Here, we review molecular and functional evidence linking Sox proteins with stem cell biology, cellular reprogramming, and disease with an emphasis on Sox2.
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