Increased plasma 7 beta-hydroxycholesterol concentrations in a population with a high risk for cardiovascular disease.
Increased plasma 7 beta-hydroxycholesterol concentrations in a population with a high risk for cardiovascular disease.
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心血管疾病高风险人群血浆 7β-羟基胆固醇浓度升高。
DOI：
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
U. Diczfalusy
中科院分区：
文献类型：
--
作者：
B. Ziedén;A. Kaminskas;M. Kristenson;Z. Kučinskienė;B. Vessby;A. Olsson;U. Diczfalusy
立陶宛50至54岁男性冠心病死亡率是瑞典的4倍。最近有人提出，传统的风险因素不能解释这种死亡率差异。然而，立陶宛男性的低密度脂蛋白显示出比瑞典男性更低的抗氧化能力。此外，立陶宛男性的血浆γ -生育酚、番茄红素和β -胡萝卜素浓度较低。在本研究中，我们测定了立陶宛和瑞典男性的血浆氧甾醇，发现立陶宛男性的血浆7 - β -羟胆固醇浓度更高，为12+/-5 (SD) ng/mL，而9+/-8 (SD) ng/mL （P=0.0011）。这种氧甾醇是一种胆固醇自氧化产物，没有迹象表明它应该有酶的起源。立陶宛男性的平均LDL氧化滞后时间较短（75+/-14 vs 90+/-13分钟，P<0.0001）， LDL亚油酸浓度较低（249+/-56 vs 292+/-54微克/毫克LDL蛋白，P<0.0001）。脂质校正γ -生育酚在维尔纽斯男性中为0.07+/-0.02 mg/mL，在维尔纽斯男性中为0.12+/-0。0.4 mg/mL （P<0.0001）。7 -羟胆固醇浓度与滞后时间呈负相关（R=-0.31， P=0.0023）。这表明，立陶宛男性较高的7 β -羟基胆固醇浓度是体内脂质过氧化增加的一个迹象。
The mortality in coronary heart disease among 50- to 54-year-old men is 4 times higher in Lithuania than in Sweden. It was recently suggested that traditional risk factors could not explain this mortality difference. LDL of Lithuanian men showed, however, a lower resistance to oxidation than that of Swedish men. In addition, the plasma concentration of gamma-tocopherol, lycopene, and beta-carotene were lower in Lithuanian men. In the present investigation, we determined plasma oxysterols in men from Lithuania and Sweden and found that the plasma concentration of 7 beta-hydroxycholesterol was higher in Lithuanian men, 12+/-5 versus 9+/-8 (SD) ng/mL (P=0.0011). This oxysterol is a cholesterol autoxidation product and there is no indication that it should have an enzymatic origin. Mean LDL oxidation lag time was shorter in Lithuanian men (75+/-14 versus 90+/-13 minutes, P<0.0001) and the concentration of LDL linoleic acid was lower (249+/-56 versus 292+/-54 microgram/mg of LDL protein, P<0.0001). Lipid corrected gamma-tocopherol was 0.07+/-0.02 mg/mL in Vilnius men and 0.12+/-0. 04 mg/mL (P<0.0001) in Linköping men. There was a negative correlation between the concentration of 7 beta-hydroxycholesterol and lag time (R=-0.31, P=0.0023). It is suggested that the higher 7 beta-hydroxycholesterol concentration in Lithuanian men is an indication of an increased in vivo lipid peroxidation.
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DOI：
10.1073/pnas.90.5.1771
发表时间：
1993-03-01
影响因子：
11.1
作者：
COONEY, RV;FRANKE, AA;MORDAN, LJ
通讯作者：
MORDAN, LJ
影响因子：
6.5
作者：
R. Patel;U. Diczfalusy;S. Dzeletovic;M. Wilson;V. Darley-Usmar
通讯作者：
R. Patel;U. Diczfalusy;S. Dzeletovic;M. Wilson;V. Darley-Usmar
DOI：
10.1097/00006205-199307000-00001
发表时间：
1993-05
期刊：
The New England journal of medicine
影响因子：
--
作者：
M. Stampfer;C. Hennekens;J. Manson;G. Colditz;B. Rosner;W. Willett
通讯作者：
M. Stampfer;C. Hennekens;J. Manson;G. Colditz;B. Rosner;W. Willett
甾醇合成抑制剂。
影响因子：
6.5
作者：
Kudo,K;Emmons,GT;Casserly,EW;Via,DP;Smith,LC;StPyrek,J;SchroepferJr,GJ
通讯作者：
SchroepferJr,GJ