AGING DECREASES THE CAPACITY OF HUMAN-SKIN TO PRODUCE VITAMIN-D3
AGING DECREASES THE CAPACITY OF HUMAN-SKIN TO PRODUCE VITAMIN-D3
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DOI：
10.1172/jci112134
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发表时间：
1985-01-01
影响因子：
15.9
通讯作者：
HOLICK, MF
中科院分区：
文献类型：
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作者：
MACLAUGHLIN, J;HOLICK, MF
对手术获得的皮肤(年龄范围为8-92岁)的评估显示，表皮中维生素D3原(7-脱氢胆固醇)的浓度随年龄的增加而降低。为了确定衰老确实降低了人类皮肤产生维生素D3的能力，将一些皮肤样本暴露在紫外线辐射下，并测定了表皮和真皮中维生素D3的含量。年轻人和老年人的表皮是维生素D3前体形成的主要部位，占皮肤产生的维生素D3前体总量的80%。将8岁和18岁受试者皮肤中产生的维生素D3前体与77岁和82岁受试者皮肤中产生的维生素D3前体的数量进行比较，发现衰老可以使皮肤产生维生素D3前体的能力降低两倍以上。对于老年人来说，认识到这种差异可能非常重要，因为他们很少将一小块皮肤暴露在阳光下，他们依赖这种暴露来满足他们的维生素D营养需求。
An evaluation of surgically obtained skin (age range, 8-92 yr) revealed that there is an age-dependent decrease in the epidermal concentrations of provitamin D3 (7-dehydrocholesterol). To ascertain that aging indeed decreased the capacity of human skin to produce vitamin D3, some of the skin samples were exposed to ultraviolet radiation and the content of previtamin D3 was determined in the epidermis and dermis. The epidermis in the young and older subjects was the major site for the formation of previtamin D3, accounting for > 80% of the total previtamin D3 that was produced in the skin. A comparison of the amount of previtamin D3 produced in the skin from the 8- and 18-yr-old subjects with the amount produced in the skin from the 77- and 82-yr-old subjects revealed that aging can decrease by greater than twofold the capacity of the skin to produce previtamin D3. Recognition of this difference may be extremely important for the elderly, who infrequently expose a small area of skin to sunlight and who depend on this exposure for their vitamin D nutritional needs.