Emergence and dissemination of clade 2.3.4.4 H5Nx influenza viruses - how is the Asian HPAI H5 lineage maintained
Emergence and dissemination of clade 2.3.4.4 H5Nx influenza viruses - how is the Asian HPAI H5 lineage maintained
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DOI：
10.1016/j.coviro.2016.02.005
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发表时间：
2016-02-01
影响因子：
5.9
通讯作者：
Donis, Ruben O.
中科院分区：
文献类型：
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作者：
Claes, Filip;Morzaria, Subhash P.;Donis, Ruben O.
2015年（1月至9月），含有A/goose/Guangdong/96-like（GD/96）HA基因的高致病性禽流感（HPAI）A（H5 N1）病毒在四大洲的鸟类中传播。2010-2011年左右，中国出现了一个新的HA Glade，名为2.3.4.4，并揭示了与N1以外的NA亚型重新分类的新倾向，与数十个早期分支不同。H5 N6和H5 N8这两种亚型已经传播到亚洲（H5 N6）、欧洲和北美（H5 N8）的国家。进化枝2.3.4.4病毒感染的特征是在家禽和一些野鸟中的低毒力，这有助于病毒通过家禽贸易和野鸟迁徙进行广泛的地理传播。
Highly pathogenic avian influenza (HPAI) A(H5N1) viruses containing the A/goose/Guangdong/96-like (GD/96) HA genes circulated in birds from four continents in the course of 2015 (Jan to Sept). A new HA Glade, termed 2.3.4.4, emerged around 2010-2011 in China and revealed a novel propensity to reassort with NA subtypes other than N1, unlike dozens of earlier clades. Two subtypes, H5N6 and H5N8, have spread to countries in Asia (H5N6), Europe and North America (H5N8). Infections by clade 2.3.4.4 viruses are characterized by low virulence in poultry and some wild birds, contributing to wide geographical dissemination of the viruses via poultry trade and wild bird migration.