A Macro-to-Micro Interface for the Control of Cellular Organization.
A Macro-to-Micro Interface for the Control of Cellular Organization.
复制标题
用于控制细胞组织的宏观到微观界面。
DOI：
10.1109/jmems.2013.2278813
复制
发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Bhatia,SangeetaN
中科院分区：
文献类型：
--
作者：
Hui,ElliotE;Li,Chun;Agrawal,Amit;Bhatia,SangeetaN
The spatial organization of cellular communities plays a fundamental role in determining intercellular communication and emergent behavior. Few tools, however, exist to modulate tissue organization at the scale of individual cells, particularly in the case of dynamic manipulation. Micromechanical reconfigurable culture achieves dynamic control of tissue organization by culturing adherent cells on microfabricated plates that can be shifted to reorganize the arrangement of the cells. Although biological studies using this approach have been previously reported, this paper focuses on the engineering of the device, including the mechanism for translating manual manipulation to precise microscale position control, fault-tolerant design for manufacture, and the synthetic-to-living interface. $\hfill{[2012\hbox{-}0374]}$
