Fluorescein sodium-guided surgery in glioblastoma multiforme: a prospective evaluation
Fluorescein sodium-guided surgery in glioblastoma multiforme: a prospective evaluation
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DOI：
10.1080/02688690701765524
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发表时间：
2008-01-01
影响因子：
1.1
通讯作者：
Ceylan, S.
中科院分区：
文献类型：
--
作者：
Koc, K.;Anik, I.;Ceylan, S.
我们评估了荧光素引导切除术对一系列 GBM 患者的大体全切除 (GTR) 和生存的影响。第 1 组由 47 名接受荧光素治疗的患者组成，第 2 组由 33 名患者组成，未使用荧光素。接受荧光素治疗的患者的中位生存时间为 43.9 周，而未接受荧光素治疗的患者的中位生存时间为 41.8 周。两组之间的生存率没有统计学上的显着差异。然而，切除范围对中位生存时间有很大影响。部分切除后的生存期为 34.3 周，GTR 后的生存期为 46.5 周。我们的数据显示，使用荧光素注射是一个简单的程序，可以使患有 GTR 的患者数量显着增加（83% vs. 55%）。我们的研究结果与最近发表的多中心 III 期随机试验相似，其中使用 5-氨基乙酰丙酸促进恶性胶质瘤的切除。
We have evaluated the influence of fluorescein-guided resection on gross total resection (GTR) and survival in a series of patients with GBM. Group 1 consisted of 47 patients given fluorescein and group 2 comprised 33 patients, on whom fluorescein was not used. Median survival time was 43.9 weeks in the patients given fluorescein and was 41.8 weeks in the non-fluorescein group. There was no statistically significant difference in survival between the two groups. However, the extent of resection had a powerful influence on the median survival time. Survival was 34.3 weeks after partial resection and 46.5 after GTR. Our data shows that the use of fluorescein injection is a simple procedure, which allows a significant increase in the number of patients having GTR (83 vs. 55%). Our findings are similar to a recently published multicentre Phase III randomized trial in which 5-aminolevulinic acid was used to facilitate resection of malignant glioma.