Relationship of polyps to cancer of the large intestine.
Relationship of polyps to cancer of the large intestine.
复制标题
息肉与大肠癌的关系。
DOI：
10.1093/jnci/84.12.962
复制
发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Verhoek-Oftedahl,W
中科院分区：
文献类型：
--
作者：
Simons,BD;Morrison,AS;Lev,R;Verhoek-Oftedahl,W
病理和流行病学证据表明，散发性（非家族性）大肠腺瘤性息肉患者发展为结直肠癌的风险很高。目的本研究的主要目的是评估组织学证实的良性结直肠息肉患者的结直肠癌死亡率。方法采用回顾性随访方法，对1959年至1975年间接受良性息肉手术时年龄在24岁至79岁之间的2872名罗德岛男性和女性进行结直肠癌死亡风险评估。结果在2872名受试者中，结直肠癌死亡率按年龄、性别和日历时间标准化，估计为罗德岛居民一般人群死亡率的1.74倍（95%可信区间= 1.44−2.09）。结肠直肠癌的死亡率在前5年的随访中高于之后的随访。息肉的数量和结直肠癌的死亡率之间几乎没有关系，息肉的大小和死亡率之间也只有适度的联系。结肠直肠癌死亡率在乙状结肠近端息肉患者是乙状结肠息肉或直肠息肉患者的两倍多。观察到的结直肠癌风险升高几乎完全局限于患有腺瘤性息肉的受试者。随着息肉中绒毛状特征的比例的增加，风险也随之增加，绒毛状腺瘤患者的风险大约是其他腺瘤性息肉患者的两倍。结论sour结果支持结肠息肉与癌症发病率之间的关系，并将其与结直肠癌死亡率之间的关系延伸。结论裸鼠原位注射人前列腺癌细胞为研究人前列腺癌的生物学和治疗提供了一种有价值的模型。
BackgroundPathologic and epidemio-logic evidence indicates that patients with sporadic (nonfamilial) adenoma-tous polyps of the large intestine are at high risk of developing colorectal cancer.PurposeOur primary goal in this study was to evaluate the colorectal cancer mortality rate among persons who have had a histologically confirmed benign colorectal polyp.MethodWe used the retrospective follow-up method to evaluate the risk of death from colorectal cancer in 2872 Rhode Island men and women who were 24 through 79 years of age at the time of surgery for benign polyps in the years 1959 through 1975.ResultsAmong 2872 subjects, the mortality from colorectal cancer, standardized for age, sex, and calendar time, was estimated as 1.74 (95% confidence interval = 1.44−2.09) times the rate in the general population of Rhode Island residents. Colorectal cancer mortality was higher in the first 5 years of follow-up than it was later. There was little relationship between the numbers of polyps and colorectal cancer mortality, and there was only a modest association between the size of polyps and mortality. Colorectal cancer mortality was more than twice as high in subjects whose polyps were proximal to the sigmoid compared with those with sigmoid or rectal polyps. The observed elevation of risk of colorectal cancer was almost entirely confined to subjects who had an adenomatous polyp. The risk increased strongly with the percentage of villous features in the polyp and was about twice as high in subjects with villous adenoma than in those with other adenomatous polyps.ConclusionsOur results support the suspected relationship between colorectal polyps and cancer incidence and extend the association to colorectal cancer mortality.ImplicationsThese data suggest that the orthotopic injection of human prostate cancer cells into the nude mouse may provide a valuable model to study the biology and therapy of human prostate cancer.