Plasma fatty acid composition, estimated desaturase activities, and their relation with the metabolic syndrome in a population at high risk of cardiovascular disease
Plasma fatty acid composition, estimated desaturase activities, and their relation with the metabolic syndrome in a population at high risk of cardiovascular disease
复制标题
DOI：
10.1016/j.clnu.2013.03.001
复制
发表时间：
2014-02-01
影响因子：
6.3
通讯作者：
Carmen Lopez-Sabater, M.
中科院分区：
文献类型：
--
作者：
Mayneris-Perxachs, Jordi;Guerendiain, Marcela;Carmen Lopez-Sabater, M.
背景和目标：代谢综合征（metabolic syndrome，MetS）是一组与心血管疾病（cardiovascular disease，CVD）和2型糖尿病（type 2 diabetes mellitus，T2DM）相关的代谢异常。由于其日益流行，它已成为一个重要的公共卫生问题。脂肪酸（FA）组成和去饱和酶活性的改变与几种代谢疾病，包括代谢综合征。本研究的目的是评估的血浆FA档案和去饱和酶的活动与代谢综合征在地中海地区人群中的高风险cvd.Methods：基线数据从427名参与者年龄在55 - 80岁谁参加了干预PREDIMED研究的关系。个体FA测定血浆和去饱和酶活性估计从产品/前体比率。结果：MetS患者中C14：0、C16：0、C16：1n-7、Delta（9）-或硬脂酰辅酶A去饱和酶（SCD）和Delta（6）去饱和酶（D6D）水平较高，而C18：2n-6水平较低。在调整了几个混杂因素后，仅C14：0、C16：0、C16：1n-7和D6D的四分位数较高与MetS患病率增加相关，而C18：2n-6的四分位数较高与MetS患病率呈负相关。C14：0、06：0、C16：1n-7、C20：3n-6、SCD和D6D的高比例以及C18：2n-6和估计的Delta（5）-去饱和酶（D5D）的比例降低与几种代谢风险因素的不良特征相关。女性表现出更多的不健康的FA模式和血脂谱比男性，但只有在那些与MetS.Conclusion：FA组成和估计的去饱和酶活性组成的高水平的SFA，SCD和D6D，和低水平的PUFA和D5D与MetS的概率增加，并提出MetS的人，特别是女性的特征。这些研究结果支持在非地中海人群中观察到的结果，其中改变的FA谱和估计的去饱和酶活性与MetS相关。(C)2013爱思唯尔有限公司和欧洲临床营养与代谢学会。All rights reserved.
Background & aims: The metabolic syndrome (MetS) is a clustering of various metabolic abnormalities which is associated with increased risk of cardiovascular disease (CVD) and type 2 diabetes mellitus. Due to its increasing prevalence, it has become an important public health concern. Altered fatty acid (FA) composition and desaturase activities have been associated with several metabolic diseases, including MetS. The aim of the present study was to evaluate the relationship of the plasma FA profile and desaturase activities with the MetS in a Mediterranean population at high risk of CVD.Methods: Baseline data from 427 participants aged 55-80 years who took part in the interventional PREDIMED study were obtained. Individual FA was determined in plasma and desaturase activities were estimated from product/precursor ratios. Odds ratios (OR) and partial correlation coefficients were used to examine these relations with MetS and its components, respectively.Results: We found higher levels of C14:0, C16:0, C16:1n-7, estimated Delta(9)- or stearoyl-CoA desaturase (SCD), and estimated Delta(6) desaturase (D6D), and lower levels of C18:2n-6 in people with MetS compared to those without it. After adjustment for several confounders, only higher quartiles of C14:0, C16:0, C16:1n-7, and D6D were found to be associated with an increasing prevalence of MetS, while higher quartiles of C18:2n-6 were inversely associated with MetS. High proportions of C14:0, 06:0, C16:1n-7, C20:3n-6, SCD, and D6D, and decreased proportions of C18:2n-6 and estimated Delta(5)-desaturase (D5D) were associated with adverse profiles of several metabolic risk factors. Women showed more unhealthy FA pattern and lipid profiles than men, but only among those with MetS.Conclusion: A FA composition and estimated desaturase activities consisting in high levels of SFA, SCD and D6D, and low levels of PUFA and D5D are associated with increased MetS probability and are characteristic of people presenting MetS, especially women. These findings support those observed in non-Mediterranean populations in which an altered FA profile and estimated desaturase activities are associated with MetS. (C) 2013 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.