Ovarian yolk sac tumor with endometrioid carcinoma arising from endometriosis in a postmenopausal woman, with special reference to expression of α-fetoprotein, sex steroid receptors, and p53
Ovarian yolk sac tumor with endometrioid carcinoma arising from endometriosis in a postmenopausal woman, with special reference to expression of α-fetoprotein, sex steroid receptors, and p53
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DOI：
10.1006/gyno.1998.5048
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发表时间：
1998-08-01
影响因子：
4.7
通讯作者：
Fujii, S
中科院分区：
文献类型：
--
作者：
Horiuchi, A;Osada, R;Fujii, S
本文报告一例绝经后妇女子宫内膜异位症所致的卵巢子宫内膜样腺癌合并卵黄囊肿瘤。临床上，该病例表现为侵袭性的病程，对化疗没有反应；患者在手术后6个月死于疾病。组织学上，肿瘤主要由子宫内膜样腺癌组成，但也表现出子宫内膜样腺癌的显微特征。肿瘤内还含有良性子宫内膜异位病变，可直接转化为子宫内膜样腺癌。免疫组织化学结果显示，不仅子宫内膜样腺癌和子宫内膜样腺癌的铜胎蛋白部分阳性。子宫内膜异位症与子宫内膜样腺癌的性激素受体和P53表达呈负相关：腺癌细胞P53阳性，性激素受体阴性，而子宫内膜异位上皮细胞性激素受体阳性，P53阴性。(C)1998年学术出版社。
A case of a yolk sac tumor (YST) with an ovarian endometrioid adenocarcinoma arising from endometriosis in a postmenopausal woman is described. Clinically, the case showed an aggressive course and did not respond to chemotherapy; the patient died of her disease 6 months after the operation. Histologically, the tumor consisted predominantly of an endometrioid adenocarcinoma, but it also showed microscopic features characteristic of YST. The tumor also contained benign endometriotic lesions with direct transition to the endometrioid adenocarcinoma. Immunohistochemical study revealed that not only the YST, but also the endometrioid adenocarcinoma was partly positive for cu-fetoprotein. There was an inverse relationship between the endometriosis and the endometrioid adenocarcinoma in terms of the expression of sex steroid receptors and p53: adenocarcinoma cells were positive for p53 but negative for sex steroid receptors, whereas endometriotic epithelial cells were positive for sex steroid receptors but negative for p53. (C) 1998 Academic Press.