The Cornea: No Difference in the Wound Healing Response to Injury Related to Whether, or Not, There's a Bowman's Layer.
The Cornea: No Difference in the Wound Healing Response to Injury Related to Whether, or Not, There's a Bowman's Layer.
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角膜：与是否有鲍曼的层相关的伤口愈合反应没有差异。
DOI：
10.3390/biom13050771
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发表时间：
2023-04-29
期刊：
影响因子：
5.5
通讯作者：
中科院分区：
文献类型：
--
作者：
鲍曼层是位于角膜前基质中的一种非细胞层，存在于人类、大多数其他灵长类动物、鸡和其他一些物种的角膜中。然而，许多其他物种，包括兔子、狗、狼、猫、老虎和狮子，没有鲍曼层。在过去的三十多年里，数以百万计的接受光屈光性角膜切除术的人通过准分子激光消融去除了中央角膜上的鲍曼层，没有明显的后遗症。先前的一项研究表明，鲍曼层对角膜内的机械稳定性没有显著的贡献。Bowman’s layer不具有屏障功能，因为在正常角膜功能和对上皮擦伤损伤的反应过程中，许多细胞因子和生长因子以及其他分子，如EBM成分perlecan，都是双向通过Bowman’s layer的。我们假设鲍曼层代表了细胞因子和生长因子介导的相互作用的一个可见指标，这种相互作用发生在角膜上皮细胞（和角膜内皮细胞）和间质角质细胞之间，通过上皮对间质角质细胞产生的调节剂的负趋化和凋亡作用来维持正常的角膜组织。由角膜上皮细胞和内皮细胞组成的白细胞介素-1 α被认为是这些细胞因子之一。在晚期Fuchs营养不良或假性大疱性角膜病变中，当上皮水肿和功能失调时，鲍曼层被破坏，纤维血管组织通常在这些角膜的上皮下和/或内发育。在桡骨角膜切开术数年后，在间质切口周围出现鲍曼样层上皮塞。虽然在角膜创面愈合方面存在物种相关的差异，甚至在同一物种内的不同品系之间也存在差异，但这些差异与鲍曼层的存在与否无关。
Bowman’s layer is an acellular layer in the anterior stroma found in the corneas of humans, most other primates, chickens, and some other species. Many other species, however, including the rabbit, dog, wolf, cat, tiger, and lion, do not have a Bowman’s layer. Millions of humans who have had photorefractive keratectomy over the past thirty plus years have had Bowman’s layer removed by excimer laser ablation over their central cornea without apparent sequelae. A prior study showed that Bowman’s layer does not contribute significantly to mechanical stability within the cornea. Bowman’s layer does not have a barrier function, as many cytokines and growth factors, as well as other molecules, such as EBM component perlecan, pass bidirectionally through Bowman’s layer in normal corneal functions, and during the response to epithelial scrape injury. We hypothesized that Bowman’s layer represents a visible indicator of ongoing cytokine and growth factor-mediated interactions that occur between corneal epithelial cells (and corneal endothelial cells) and stromal keratocytes that maintain the normal corneal tissue organization via negative chemotactic and apoptotic effects of modulators produced by the epithelium on stromal keratocytes. Interleukin-1 alpha, produced constitutively by corneal epithelial cells and endothelial cells, is thought to be one of these cytokines. Bowman’s layer is destroyed in corneas with advanced Fuchs’ dystrophy or pseudophakic bullous keratopathy when the epithelium becomes edematous and dysfunctional, and fibrovascular tissue commonly develops beneath and/or within the epithelium in these corneas. Bowman’s-like layers have been noted to develop surrounding epithelial plugs within the stromal incisions years after radial keratotomy. Although there are species-related differences in corneal wound healing, and even between strains within a species, these differences are not related to the presence or absence of Bowman’s layer.
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影响因子：
4.4
作者：
Gealy, Claire;Hayes, Anthony J.;Ralphs, James R.
通讯作者：
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DOI：
10.1016/j.oftal.2016.01.012
发表时间：
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影响因子：
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