Effect of ethanol on memory consolidation in mice Antagonism by the imidazobenzodiazepine Ro 15-4513 and decrement by familiarization with the environment
Effect of ethanol on memory consolidation in mice Antagonism by the imidazobenzodiazepine Ro 15-4513 and decrement by familiarization with the environment
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乙醇对小鼠记忆巩固的影响 咪唑并苯二氮卓 Ro 15-4513 的拮抗作用和熟悉环境后的递减作用
DOI：
10.1016/0166-4328(90)90044-f
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发表时间：
1990
影响因子：
2.7
通讯作者：
R. Populin
中科院分区：
文献类型：
--
作者：
C. Castellano;R. Populin
以CD1小鼠为实验对象，进行了三组实验。在第一组实验中，训练后给药乙醇（1或2 g/kg）损害了动物的记忆，而咪唑苯二氮卓15-4513（5或10 mg/kg，但不是2.5 mg/kg）改善了动物的记忆性能。在第二组实验中，Ro 15-4513本身无效剂量（2.5 mg/kg）可拮抗乙醇（1和2 kg/kg）的作用。这些结果是在这些药物与gaba能系统相互作用的基础上讨论的。在第三组实验中，将熟悉该装置的小鼠与不熟悉该装置的小鼠进行比较，发现乙醇对有经验的小鼠的记忆过程的损害效果较差。这些结果讨论了情绪的衰减，导致受损的保留，在训练后的乙醇管理。
Three sets of experiments were carried out with CD1 mice tested in a one-trial inhibitory avoidance task. In a first set of experiments the posttraining administration of ethanol (1 or 2 g/kg) impaired, while that of the imidazobenzodiazepine Ro 15-4513 (5 or 10, but not 2.5 mg/kg) improved the retention performance of the animals. In a second set of experiments a by itself ineffective dose of Ro 15-4513 (2.5 mg/kg) antagonized the effect of ethanol (1 and 2 kg/kg). These results are discussed on the basis of the interaction of these drugs with the GABAergic system. In a third set of experiments, in which the performances of mice familiarized with the apparatus were compared with those of non-familiarized mice, ethanol was less effective in impairing memory processes of the experienced subjects. These results are discussed in terms of attenuation of emotionality, resulting in impaired retention, following posttraining ethanol administration.
DOI：
--
发表时间：
1982-12
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
G. Frye;G. Breese
通讯作者：
G. Frye;G. Breese