Biomimetic Total Synthesis of (±)-Carbocyclinone-534 Reveals Its Biosynthetic Pathway.
Biomimetic Total Synthesis of (±)-Carbocyclinone-534 Reveals Its Biosynthetic Pathway.
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DOI：
10.1021/acs.orglett.0c02865
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发表时间：
2020-10
期刊：
影响因子：
5.2
通讯作者：
Chunlei Qu;Xianwen Long;Yueqian Sang;Min Zhang;Xiaoli Zhao;Xiao-song Xue;Jun Deng
中科院分区：
文献类型：
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作者：
Chunlei Qu;Xianwen Long;Yueqian Sang;Min Zhang;Xiaoli Zhao;Xiao-song Xue;Jun Deng
Carbocyclinone-534 is a new antibiotic produced after the metabolism of tapinarof. We identify a biomimetic total synthesis of carbocyclinone-534 in eight steps by taking advantage of an intermolecular Diels-Alder homodimerization/dehydrogenation/intramolecular Diels-Alder cycloaddition cascade. This synthetic sequence provides direct experimental evidence for revealing the biosynthetic pathway of carbocyclinone-534.
