The gene encoding early growth response 2, a target of the transcription factor NFAT, is required for the development and maturation of natural killer T cells.
The gene encoding early growth response 2, a target of the transcription factor NFAT, is required for the development and maturation of natural killer T cells.
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由磷酸酶钙调神经磷酸酶和转录因子NFAT传递的信号对自然杀伤T（NKT）细胞的发育和功能的影响尚不清楚。在这份报告中，我们证明，转录因子早期生长反应2（Egr 2），NFAT的靶基因，是专门需要的NKT细胞的个体发育，但不是传统的CD 4+或CD 8 + T细胞。NKT细胞在缺乏Egr 1或Egr 3的情况下正常发育，这表明Egr 2是NKT细胞分化的特异性调节剂。我们发现Egr 2在NKT细胞的选择、存活和成熟中起重要作用。我们的研究结果强调了钙调神经磷酸酶-NFAT-Egr 2途径在NKT淋巴细胞谱系发育中的重要性。
The influence of signals transmitted by the phosphatase calcineurin and the transcription factor NFAT on the development and function of natural killer T (NKT) cells is unclear. In this report, we demonstrate that the transcription factor early growth response 2 (Egr2), a target gene of NFAT, was specifically required for the ontogeny of NKT cells but not that of conventional CD4+ or CD8+ T cells. NKT cells developed normally in the absence of Egr1 or Egr3, which suggests that Egr2 is a specific regulator of NKT cell differentiation. We found that Egr2 was important in the selection, survival and maturation of NKT cells. Our findings emphasize the importance of the calcineurin-NFAT-Egr2 pathway in the development of the NKT lymphocyte lineage.
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