Cancer Activation and Polymorphisms of Human Cytochrome P450 1B1.
Cancer Activation and Polymorphisms of Human Cytochrome P450 1B1.
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DOI：
10.5487/tr.2016.32.2.089
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发表时间：
2016-04
影响因子：
2.3
通讯作者：
Kim D
中科院分区：
文献类型：
--
作者：
Chun YJ;Kim D
人细胞色素P450酶（P450，CYP）是代谢各种外源性和内源性化合物的主要氧化催化剂。许多致癌物质只有在代谢活化后才能诱发癌症，P450酶在这一现象中起着重要作用。P450 1B 1介导许多前致癌化学物质和致癌雌激素的生物活化。对多环芳香碳、杂环和芳香胺的氧化反应以及17β-雌二醇的4-羟基化反应进行催化。P450 1B 1表达增强促进癌细胞增殖和转移。P450 1B 1至少有25种多态性变体，其中一些已被报道与眼部疾病相关。此外，P450 1B 1多态性可以极大地影响许多前致癌化合物的代谢活化。因此，有必要了解这些物质的代谢活化与P450 1B 1基因多态性之间的关系，以制定合理的策略来预防其对人类健康的毒性作用。
Human cytochrome P450 enzymes (P450s, CYPs) are major oxidative catalysts that metabolize various xenobiotic and endogenous compounds. Many carcinogens induce cancer only after metabolic activation and P450 enzymes play an important role in this phenomenon. P450 1B1 mediates bioactivation of many procarcinogenic chemicals and carcinogenic estrogen. It catalyzes the oxidation reaction of polycyclic aromatic carbons, heterocyclic and aromatic amines, and the 4-hydroxylation reaction of 17β-estradiol. Enhanced expression of P450 1B1 promotes cancer cell proliferation and metastasis. There are at least 25 polymorphic variants of P450 1B1 and some of these have been reported to be associated with eye diseases. In addition, P450 1B1 polymorphisms can greatly affect the metabolic activation of many procarcinogenic compounds. It is necessary to understand the relationship between metabolic activation of such substances and P450 1B1 polymorphisms in order to develop rational strategies for the prevention of its toxic effect on human health.