Serologic Markers for Ebolavirus Among Healthcare Workers in the Democratic Republic of the Congo
Serologic Markers for Ebolavirus Among Healthcare Workers in the Democratic Republic of the Congo
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DOI：
10.1093/infdis/jiy499
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发表时间：
2019-02-15
影响因子：
6.4
通讯作者：
Rimoin, Anne W.
中科院分区：
文献类型：
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作者：
Hoff, Nicole A.;Mukadi, Patrick;Rimoin, Anne W.
医疗机构在埃博拉病毒（EBOV）爆发的传播中发挥了重要作用。卫生保健工作者（HCW）与EBOV感染患者接触的风险增加，特别是如果没有严格采取安全预防措施。我们进行了一项血清调查，以确定刚果民主共和国Boiler卫生区（2014年EBOV爆发的地点）的HCW中针对多种EBOV抗原的血清阳性率。访谈和标本收集565同意HCW。总体而言，234名（41.4%）入组的HCW对至少一种EBOV蛋白具有反应性：159名（28.1%）对抗糖蛋白免疫球蛋白G（IgG）具有血清反应性，89名（15.8%）对抗核蛋白IgG具有血清反应性，54名（9.5%）为VP40阳性。此外，16例（2.8%）HCW的血清显示出中和能力。这些数据表明，尽管从未出现埃博拉病毒疾病症状，但相当比例的HCW具有中和病毒的能力，这突出了EBOV感染和进展的一个重要且记录不足的方面。
Healthcare settings have played a major role in propagation of Ebola virus (EBOV) outbreaks. Healthcare workers (HCWs) have elevated risk of contact with EBOV-infected patients, particularly if safety precautions are not rigorously practiced. We conducted a serosurvey to determine seroprevalence against multiple EBOV antigens among HCWs of Boende Health Zone, Democratic Republic of the Congo, the site of a 2014 EBOV outbreak. Interviews and specimens were collected from 565 consenting HCWs. Overall, 234 (41.4%) of enrolled HCWs were reactive to at least 1 EBOV protein: 159 (28.1%) were seroreactive for anti-glycoprotein immunoglobulin G (IgG), 89 (15.8%) were seroreactive for anti-nucleoprotein IgG, and 54 (9.5%) were VP40 positive. Additionally, sera from 16 (2.8%) HCWs demonstrated neutralization capacity. These data demonstrate that a significant proportion of HCWs have the ability to neutralize virus, despite never having developed Ebola virus disease symptoms, highlighting an important and poorly documented aspect of EBOV infection and progression.