Interleukin-28B Genetic Variants and Hepatitis Virus Infection by Different Viral Genotypes
Interleukin-28B Genetic Variants and Hepatitis Virus Infection by Different Viral Genotypes
复制标题
DOI：
10.1002/hep.23624
复制
发表时间：
2010-07-01
期刊：
影响因子：
13.5
通讯作者：
Francisca Gonzalez-Escribano, Maria
中科院分区：
文献类型：
--
作者：
Antonio Montes-Cano, Marco;Raul Garcia-Lozano, Jose;Francisca Gonzalez-Escribano, Maria
遗传宿主因素可能改变丙型肝炎病毒（HCV）感染的过程。最近，一项全基因组扫描报告了IL28B位点与HCV感染治疗反应的关联。本研究的目的是在一个由731名西班牙人组成的队列中调查该基因座与HCV感染结果的关系。其中，持续感染的284人，自然清除病毒的69人，未感染的378人。采用TaqMan 5′等位基因鉴别法对IL28B位点rs12979860 （C>T）进行基因分型。CC基因型在非1型病毒感染者中被过度代表（66.7% vs 39.1%, P = 8.5 x 10(-5)，优势比[OR] = 0.32, 95%可信区间[CI] 0.17-0.60）；感染自发消退患者(72.5% vs 45.6%持续感染患者，P = 6.2 x 10(-5), OR = 0.32；95%置信区间,0.18 - -0.57);最后是持续缓解的患者（60.2% vs 32.1%）， P = 3.1 x 10(-5), OR = 0.31；95%可信区间,0.17 - -0.56)。结论：我们发现不同的病毒基因型感染率取决于IL28B变异，以及该基因座与自然和治疗介导的反应的关联。(肝脏病学2010;52:33-37)
Genetic host factors may modify the course of the hepatitis C virus (HCV) infection. Very recently, a genome-wide scan that reported association of the IL28B locus with response to treatment in HCV infection was published. The aim of the current study was to investigate the relationship of this locus with outcome of HCV infection in a cohort constituted by a total of 731 Spanish individuals. From these, 284 were subjects with persistent infection, 69 were individuals who naturally cleared the virus, and 378 were noninfected subjects. Genotyping of the rs12979860 (C>T) in the IL28B locus was performed using a TaqMan 5' allelic discrimination assay. The CC genotype was overrepresented among patients infected with viral genotypes non-1 (66.7% versus 39.1% in patients infected with viral genotype-1, P = 8.5 x 10(-5), odds ratio [OR] = 0.32, 95% confidence interval [CI] 0.17-0.60); patients with spontaneous resolution of infection (72.5% versus 45.6% of the individuals with persistent infection, P = 6.2 x 10(-5), OR = 0.32; 95%CI, 0.18-0.57); and lastly, patients with sustained response (60.2% versus 32.1% found in patients with non-sustained response, P = 3.1 x 10(-5), OR = 0.31; 95%CI, 0.17-0.56). Conclusion: We have found different rates of viral genotype infection depending on the IL28B variant as well as an association of this locus with natural and treatment-mediated response. (HEPATOLOGY 2010;52:33-37)