Fiber Organization Has Little Effect on Electrical Activation Patterns During Focal Arrhythmias in the Left Atrium.
Fiber Organization Has Little Effect on Electrical Activation Patterns During Focal Arrhythmias in the Left Atrium.
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DOI：
10.1109/tbme.2022.3223063
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发表时间：
2023-05
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在过去的二十年里，有一个稳定的趋势，发展的逼真模型的心脏传导的细节水平不断提高。然而，由于组织和细胞尺度数据的可用性有限，使模型更加逼真使其个性化和在临床实践中的使用变得复杂。一个这样的限制是在临床环境中获得有关心肌纤维组织的信息。在这项研究中，我们研究了一个嵌合模型的左心房，利用临床衍生的患者特定的心房几何形状和一个现实的，但外国的一个给定的患者纤维组织。我们发现，即使是纤维组织的显着变化有一个相对较小的影响，在定期起搏的时空激活模式。对于给定的起搏部位，所有受试纤维组织的激动标测图非常相似。
Over the past two decades there has been a steady trend towards the development of realistic models of cardiac conduction with increasing levels of detail. However, making models more realistic complicates their personalization and use in clinical practice due to limited availability of tissue and cellular scale data. One such limitation is obtaining information about myocardial fiber organization in the clinical setting. In this study, we investigated a chimeric model of the left atrium utilizing clinically derived patient-specific atrial geometry and a realistic, yet foreign for a given patient fiber organization. We discovered that even significant variability of fiber organization had a relatively small effect on the spatio-temporal activation pattern during regular pacing. For a given pacing site, the activation maps were very similar across all fiber organizations tested.