Dioxopiperazine Alkaloids Produced by the Marine Mangrove Derived Endophytic Fungus Eurotium rubrum
Dioxopiperazine Alkaloids Produced by the Marine Mangrove Derived Endophytic Fungus Eurotium rubrum
复制标题
海洋红树林内生真菌红色散囊菌产生的二氧代哌嗪生物碱
DOI：
10.1002/hlca.200890202
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发表时间：
2008-01-01
影响因子：
1.8
通讯作者：
Wang, Bin-Gui
中科院分区：
文献类型：
--
作者：
Li, Dong-Li;Li, Xiao-Ming;Wang, Bin-Gui
从红树芙萝（hi芙萝）茎内组织中分离出内生真菌rubrum Eurotium rubrum，对其进行培养，分离出2个新的二氧哌哌啶衍生物，分别为dehydrovariecolorin L(1)和dehydroechinulin(2)，以及8个已知的二氧哌哌啶化合物，包括variecolorin L(3)、echinulin(4)、isoechinulin A(5)、dihydroxyisoechinulin A(6)、preechinulin(7)、neoechinulin A(8)、neoechinulin E(9)、和cryptoechinuline D（10）。分离化合物的结构是通过对其光谱数据的广泛分析以及与文献的比较来确定的。研究了化合物1、2、9和10对a，a-二苯基- β -苦酰肼（DPPH）自由基的清除活性。此外，对新化合物1和2对P-388、HL-60和A549细胞系的细胞毒活性进行了评价。
Cultivation of the fungal strain Eurotium rubrum, an endophytic fungus that was isolated from the inner tissue of stems of the mangrove plant Hibiscus tiliaceus, resulted in the isolation of two new dioxopiperazine derivatives, namely, dehydrovariecolorin L (1) and dehydroechinulin (2), together with eight known dioxopiperazine compounds including variecolorin L (3), echinulin (4), isoechinulin A (5), dihydroxyisoechinulin A (6), preechinulin (7), neoechinulin A (8), neoechinulin E (9), and cryptoechinuline D (10). The structures of the isolated compounds were determined by extensive analysis of their spectroscopic data as well as by comparison with literature. Compounds 1, 2, 9, and 10 were investigated for their a,a-diphenyl-beta-picrylhydrazyl (DPPH) radical-scavenging activity. In addition, the new compounds, 1 and 2, were evaluated for their cytotoxic activity against the P-388, HL-60, and A549 cell lines.