A CASE OF KERATITIS DUE TO ACANTHAMOEBA IN NEW-YORK, NEW-YORK, AND FEATURES OF 10 CASES
A CASE OF KERATITIS DUE TO ACANTHAMOEBA IN NEW-YORK, NEW-YORK, AND FEATURES OF 10 CASES
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DOI：
10.1093/infdis/143.5.662
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发表时间：
1981-01-01
影响因子：
6.4
通讯作者：
STEVENS, AR
中科院分区：
文献类型：
--
作者：
MA, P;WILLAERT, E;STEVENS, AR
纽约纽约一名男子感染了由A. castellanii。由于最初未怀疑阿米巴是致病微生物，因此诊断延迟。培养分离株和角膜切片中的阿米巴经鉴定为A. castellanii通过免疫荧光使用抗血清，该物种的质膜。快速琼脂盘扩散法显示变形虫对匹马菌素（0.5%）敏感，对> 1000 μ g/ml水平的巴龙霉素、多粘菌素B-杆菌肽-新霉素、吖啶黄、5-氟胞嘧啶、阿替霉素B、庆大霉素和甲氧苄啶-磺胺甲恶唑具有抗性。该感染是文献中报道的第8例棘阿米巴角膜炎，并强调临床医生需要在细菌、真菌和病毒治疗无效的眼部感染的鉴别诊断中考虑棘阿米巴感染。
A man in New York, New York, contracted keratitis caused by A. castellanii. The diagnosis was delayed because amoebae were not initially suspected as the causative organism. The culture isolate and the amoebae in corneal sections were identified as A. castellanii by immunofluorescence using antiserum to plasma membranes of this species. The rapid agar disk diffusion method showed that amoebae were susceptible to pimaricin (0.5%) and resistant to > 1000-.mu.g/ml levels of paromomycin, polymyxin B-bacitracin-neomycin, acriflavine, 5-fluorocytosine, amphotericin B, gentamicin and trimethoprim-sulfamethoxazole. The infection is the 8th case reported in the literature of acanthamoebic keratitis, and emphasizes the need for clinicians to consider acanthamoebic infection in the differential diagnosis of eye infections that fail to respond to bacterial, fungal and viral therapy.