Manipulating time-to-plan alters patterns of brain activation during the Fitts' task
Manipulating time-to-plan alters patterns of brain activation during the Fitts' task
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DOI：
10.1007/s00221-009-1726-4
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发表时间：
2009-04-01
影响因子：
2
通讯作者：
Wessel, B. D.
中科院分区：
文献类型：
--
作者：
Boyd, Lara A.;Vidoni, E. D.;Wessel, B. D.
费茨定律预测，在运动过程中，速度和准确性之间存在一个基本的权衡。过去对费茨定律的研究并没有描述预先计划即将到来的快速准确的运动是否会影响大脑激活的行为或模式。采用事件相关功能磁共振成像（fMRI）范式，采用经典Fitts任务的离散版本，研究了快速、目标导向的目标运动的提前计划和运动难度的神经相关性。我们的行为数据显示，在反应时间，初始运动速度和终点精度的基础上操纵的时间来计划动作和响应难度的强烈差异。我们发现了与执行Fitts任务相关的神经网络调制，该任务取决于计划即将到来的运动和运动困难的时间可用性。具体来说，当有时间计划即将到来的运动时，内侧额回（BA 10），前SMA（BA 6），壳核和小脑小叶VI是唯一活跃的计划运动。此外，它们的激活与运动的行为测量相关。与此相反，操纵运动困难调用不同的模式的大脑激活的区域，已知参与运动控制，包括辅助运动区（BA 6），感觉运动皮层（BA 4，3，2）和壳核。我们的发现，内侧额回（BA 10）是重要的离散，快速和准确的运动扩展了已知的作用，这个大脑区域，在过去已被确定为一个认知处理系统，支持刺激导向的出席。我们现在将这一概念扩展到包括运动功能，例如用于处理快速、目标导向的目标运动的运动功能。
Fitts' law predicts that there is an essential trade-off between speed and accuracy during movement. Past investigations of Fitts' law have not characterized whether advance planning of upcoming fast and accurate movements impacts either behavior or patterns of brain activation. With an event-related functional magnetic resonance imaging (fMRI) paradigm, we investigated the neural correlates of advance planning and movement difficulty of rapid, goal-directed aimed movements using a discrete version of the classic Fitts' task. Our behavioral data revealed strong differences in response time, initial movement velocity, and end-point accuracy based on manipulation of both time to plan movements and response difficulty. We discovered a modulation of the neural network associated with executing the Fitts' task that was dependent on the availability of time to plan the upcoming movement and motor difficulty. Specifically, when time to plan for the upcoming movement was available, medial frontal gyrus (BA 10), pre-SMA (BA 6), putamen and cerebellar lobule VI were uniquely active to plan movements. Further, their activation correlated with behavioral measures of movement. In contrast, manipulating movement difficulty invoked a different pattern of brain activations in regions that are known to participate in motor control, including supplementary motor area (BA 6), sensory motor cortex (BA 4, 3, 2) and putamen. Our finding that medial frontal gyrus (BA 10) was important for discrete, fast and accurate movements expands the known role of this brain region, which in the past has been identified as a cognitive processing system supporting stimulus-oriented attending. We now extend this conceptualization to include motor functions such as those employed for processing for rapid, goal-directed aimed movements.