FUNCTIONAL COMPETENCE OF DENDRITIC CELLS OF AGING C57BL/6 MICE
FUNCTIONAL COMPETENCE OF DENDRITIC CELLS OF AGING C57BL/6 MICE
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DOI：
10.1111/j.1365-3083.1986.tb02166.x
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发表时间：
1986-11-01
影响因子：
3.7
通讯作者：
MURAMATSU, S
中科院分区：
文献类型：
--
作者：
KOMATSUBARA, S;CINADER, B;MURAMATSU, S
Higly polymorphic age-dependent differences in progression of T and B cells have been found in various strains of inbred mice. In the immune system of C57BL/6 mice these occur first in B cells and, later in life, in T cells. In this paper, we have examined the progression in the functional capacity of C57BL/6 dendritic cells (DC). Age-dependent changes were found in the syngeneic mixed leucocyte reaction, in which the stimulatory capacity of DC increased with age. This increase was independent of the age of the donor of the serum that was added to the culture, and occurred when young donors provided the T cells. Age-dependent changes in DC properties were not detected in terms of direct plaque-forming response, response to concanavalin A, or in the allogeneic mixed leucocyte reaction.
