Neurocognitive functioning in patients with glioma of the left and right temporal lobes.
Neurocognitive functioning in patients with glioma of the left and right temporal lobes.
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DOI：
10.1007/s11060-016-2114-0
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发表时间：
2016-06
影响因子：
3.9
通讯作者：
Wefel JS
中科院分区：
文献类型：
--
作者：
Noll KR;Ziu M;Weinberg JS;Wefel JS
神经胶质瘤患者经常遭受神经认知功能（NCF）的缺陷，但很少有研究评估NCF在局部神经胶质瘤患者手术前。103例经组织学证实的右侧（RTL：n = 30; 57%胶质母细胞瘤）或左侧颞叶（LTL：n = 73; 49%胶质母细胞瘤）胶质瘤患者（M年龄= 52.0; M教育= 14.6年）完成了术前神经心理学评估。75%的患者发现NCF受损。值得注意的是，RTL胶质瘤患者的言语记忆和执行功能最常受损，与LTL组的比率相似。尽管如此，χ2检验显示LTL组在注意力和物体命名测试中的损伤率显著较高（p ≤ .05）。独立样本t检验显示，LTL胶质瘤患者在注意力（p = 0.01）、言语学习和记忆（p = 0.05）以及语言（p <0.03）方面的平均表现也显着低于RTL患者。观察到一种趋势，即前部LTL肿瘤与言语学习能力降低和内侧LTL病变与延迟回忆问题相关，尽管涉及多个LTL区域病变的患者在所有言语记忆测量中表现出最大的困难。在控制FLAIR体积和肿瘤组织学后，NCF性能的显著组间差异仍然存在。这些研究结果表明，颞叶胶质瘤经常出现受损的NCF，尽管与LTL患者相比，RTL患者的损伤通常较轻。尽管如此，RTL组中相对频繁的言语记忆障碍强调了言语记忆过程的双边性。
Patients with glioma frequently suffer from deficits of neurocognitive functioning (NCF), though few studies have assessed NCF in localized glioma patients prior to surgery. One hundred and three patients (M age = 52.0; M education = 14.6 years) with histologically confirmed glioma in the right (RTL: n = 30; 57 % glioblastoma) or left temporal lobe (LTL: n = 73; 49 % glioblastoma) completed presurgical neuropsychological assessment. Impairment of NCF was identified in 75 % of all patients. Notably, patients with RTL glioma were most frequently impaired on measures of verbal memory and executive functioning, and at similar rates as the LTL group. Nonetheless, χ2 tests revealed that impairment rates were significantly higher in the LTL group on attention and object naming tests (p ≤ .05). Independent-samples t-tests revealed that mean performances of patients with LTL glioma were also significantly below RTL patients on measures of attention (p = .01), verbal learning and memory (p = .05), and language (p <.03). A trend was observed in which anterior LTL tumors were associated with reduced verbal learning and medial LTL lesions with delayed recall problems, though patients with lesions involving multiple LTL regions exhibited the greatest difficulty across all verbal memory measures. Significant group differences in NCF performances remained so after controlling for FLAIR volume and tumor histology. These findings indicate that temporal lobe glioma frequently present with impaired NCF, though impairments are often milder in RTL compared to LTL patients. Nonetheless, the relatively frequent verbal memory impairment in the RTL group underscores the bilaterality of verbal memory processes.